While inner ear disorders are common, our ability to intervene and recover their sensory
function is limited. In vitro models of the inner ear, like the organoid system, could aid in …

Current estimates suggest that nearly half a billion people worldwide are affected by hearing
loss. Because of the major psychological, social, economic, and health ramifications …

To the Editor—Biologists are important stakeholders in genomic data, both as data
generators and as users of genomic data resources. Tools to efficiently visualize and …

Different types of spiral ganglion neurons (SGNs) are essential for auditory perception by
transmitting complex auditory information from hair cells (HCs) to the brain. Here, we use …

Noise-induced hearing loss (NIHL) results from a complex interplay of damage to the
sensory cells of the inner ear, dysfunction of its lateral wall, axonal retraction of type 1C …

Progressive functional deterioration in the cochlea is associated with age-related hearing
loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains …

Loss of sensory hair cells (HCs) in the mammalian inner ear leads to permanent hearing
and vestibular defects, whereas loss of HCs in zebrafish results in their regeneration. We …

Functional molecular characterization of the cochlea has mainly been driven by the
deciphering of the genetic architecture of sensorineural deafness. As a result, the search for …

Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …

Sound stimulus is encoded in mice by three molecularly and physiologically diverse
subtypes of sensory neurons, called Ia, Ib, and Ic spiral ganglion neurons (SGNs). Here, we …