Metabolites are the small biological molecules involved in energy conversion and
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …

Metabolomics is an emerging approach in a systems biology field. Due to continuous
development in advanced analytical techniques and in bioinformatics, metabolomics has …

Mass spectrometry (MS) and nuclear magnetic resonance (NMR) have evolved as the most
common techniques in metabolomics studies, and each brings its own advantages and …

Hydrophilic interaction liquid chromatography (HILIC) has emerged as a valuable
complimentary technique to reversed-phase (RP), being especially suited for the analysis of …

Hydrophilic interaction chromatography (HILIC) is valuable alternative to reversed-phase
liquid chromatography separations of polar, weakly acidic or basic samples. In principle, this …

Based on publication and citation numbers liquid chromatography (LC–MS) has become the
major analytical technology in the field of global metabolite profiling. This dominance reflects …

Untargeted, global metabolite profiling (often described as metabonomics or metabolomics)
represents an expanding research topic and is, potentially, a major pillar for systems biology …

Metabolomics offers a revolutionary framework for phenotyping individuals at a molecular
level that is needed for new breakthroughs in cell biology and personalized medicine. 1− 3 …

Liquid chromatography (LC) hyphenated to mass spectrometry is currently the most widely
used means of determining metabolic phenotypes via both untargeted and targeted …

Although the objective of any 'omic science is broad measurement of its constituents, such
coverage has been challenging in metabolomics because the metabolome is comprised of a …