A Deep Dive into PDE5 Inhibition: Innovative Discoveries via Virtual Screening

A Debnath, H Chaudhary, P Sharma… - Letters in Drug …, 2024 - benthamdirect.com
Background PDE5 inhibitors have had a surge in popularity over the last decade owing to
their efficacy in the treatment of erectile dysfunction, coronary vasculopathy, and pulmonary …

A novel standard‐free detection of adulteration method for sildenafil derivatives in dietary supplements

D Lv, D Wang, D Li, D Guo, M Qi… - Biomedical …, 2024 - Wiley Online Library
The rapid and accurate detection of illegal adulteration of chemical drugs into dietary
supplements is a big challenge in the food chemistry field. Detection of compounds without a …

One-pot Multicomponent Reaction: An Efficient Synthesis of 4-(Het) ArylSubstituted Pyrazolo-Quinolinones

HK Beker, Ş Kaban - Current Organic Synthesis, 2024 - ingentaconnect.com
Introduction: Pyrazolo-quinolinones (PQs) are a versatile class of Organic chemistry and it
was found that they have very advanced functionally promising as selective compounds due …

[引用][C] Trends in Enzyme Inhibition and Activation in Drug Design–Part-I

A Geronikaki - Current Topics in Medicinal Chemistry, 2019 - ingentaconnect.com
The research for finding PTP1B inhibitors started with the design of molecules mimicking the
tyrosine substrate of the enzyme and revealed the main requirements for small inhibitors …