Cancer is a global issue majorly affecting developing countries. According to a survey, 63%
of deaths due to cancer are reported from developing countries. There are different …

Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability
to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at …

Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

Breast cancer has the highest incidence and death rate among cancers in women
worldwide. In particular, metastatic estrogen receptor negative (ER–) breast cancer and …

UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in
mammalian cells. The establishment domains are defined, including E3 ligase function, but …

In 1997 a mutation in the a-synuclein (SNCA) gene was associated with familial autosomal
dominant Parkinson's disease (PD). Since then, several loci (PARK1‐15) and genes have …

Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …

Protein ubiquitination and deubiquitination participate in a number of biological processes,
including cell growth, differentiation, transcriptional regulation, and oncogenesis. Ubiquitin C …

Background Breast cancer (BrCa) is a complex disease driven by aberrant gene alterations
and environmental factors. Recent studies reveal that abnormal epigenetic gene regulation …

Purpose: Nasopharyngeal carcinoma is prevalent in southern China and Southeast Asia,
with distinct geographic and ethnic distribution. One candidate susceptibility locus has been …