In bacteria, more than half of the genes in the genome are organized in operons. In contrast,
in eukaryotes, functionally related genes are usually dispersed across the genome. There …

Microbes and plants produce a huge array of secondary metabolites that have important
ecological functions. These molecules have long been exploited in medicine as antibiotics …

The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to
humans and animals, yet coordinated transcriptional regulation of gene clusters remains …

Chromatin, composed of DNA wrapped around an octamer of histones, is the relevant
substrate for all genetic processes in eukaryotic nuclei. Changes in chromatin structure are …

Filamentous fungi produce a vast array of small molecules called secondary metabolites,
which include toxins as well as antibiotics. Coregulated gene clusters are the hallmark of …

Secondary metabolite biosynthesis genes in fungi are usually physically linked and
organized in large gene clusters. The physical linkage of genes involved in the same …

The last decade brought a still growing experimental evidence of mobilome impact on host's
gene expression. We systematically analysed genomic location of transposable elements …

Gene clusters for the synthesis of secondary metabolites are a common feature of microbial
genomes. Well‐known examples include clusters for the synthesis of antibiotics in …

Like other domains of life, research into the biology of filamentous microbes has greatly
benefited from the advent of whole-genome sequencing. Next-generation sequencing …

Fungal secondary metabolites are small molecules that exhibit diverse biological activities
exploited in medicine, industry and agriculture. Their biosynthesis is governed by co …