Frailty: implications for clinical practice and public health

EO Hoogendijk, J Afilalo, KE Ensrud, P Kowal, G Onder… - The Lancet, 2019 - thelancet.com
Frailty is an emerging global health burden, with major implications for clinical practice and
public health. The prevalence of frailty is expected to rise alongside rapid growth in the …

Fifteen years of progress in understanding frailty and health in aging

K Rockwood, SE Howlett - BMC medicine, 2018 - Springer
The notion of frailty has evolved for more than 15 years. Although there is no consensus
definition, frailty reflects a state of increased vulnerability to adverse health outcomes for …

Measuring frailty in Medicare data: development and validation of a claims-based frailty index

DH Kim, S Schneeweiss, RJ Glynn… - The Journals of …, 2018 - academic.oup.com
Background Frailty is a key determinant of health status and outcomes of health care
interventions in older adults that is not readily measured in Medicare data. This study aimed …

Association between initiation of pulmonary rehabilitation after hospitalization for COPD and 1-year survival among Medicare beneficiaries

PK Lindenauer, MS Stefan, PS Pekow, KM Mazor… - Jama, 2020 - jamanetwork.com
Importance Meta-analyses have suggested that initiating pulmonary rehabilitation after an
exacerbation of chronic obstructive pulmonary disease (COPD) was associated with …

Validation of a claims-based frailty index against physical performance and adverse health outcomes in the health and retirement study

DH Kim, RJ Glynn, J Avorn, LA Lipsitz… - The Journals of …, 2019 - academic.oup.com
Background A claims-based frailty index (CFI) was developed based on a deficit-
accumulation approach using self-reported health information. This study aimed to …

Natural history of coronavirus disease 2019: risk factors for hospitalizations and deaths among> 26 million US Medicare beneficiaries

HS Izurieta, DJ Graham, Y Jiao, M Hu… - The Journal of …, 2021 - academic.oup.com
Background The current study was performed to evaluate risk factors for severe coronavirus
disease 2019 (COVID-19) outcomes among Medicare beneficiaries during the pandemic's …

Severe hypocalcemia with denosumab among older female dialysis-dependent patients

ST Bird, ER Smith, K Gelperin, TH Jung, A Thompson… - JAMA, 2024 - jamanetwork.com
Importance Dialysis-dependent patients experience high rates of morbidity from fractures,
yet little evidence is available on optimal treatment strategies. Chronic kidney disease …

Measuring frailty in administrative claims data: comparative performance of four claims-based frailty measures in the US Medicare data

DH Kim, E Patorno, A Pawar, H Lee… - The Journals of …, 2020 - academic.oup.com
Background There has been increasing effort to measure frailty in the US Medicare data.
The performance of claims-based frailty measures has not been compared. Methods This …

Long-term comparative effectiveness and safety of dabigatran, rivaroxaban, apixaban and edoxaban in patients with atrial fibrillation: A nationwide cohort study

M Grymonprez, TL De Backer, X Bertels… - Frontiers in …, 2023 - frontiersin.org
Background: Although non-vitamin K antagonist oral anticoagulants (NOACs) are
recommended over vitamin K antagonists (VKAs) in atrial fibrillation (AF) management …

Effectiveness and safety of oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-analysis

M Grymonprez, S Steurbaut, TL De Backer… - Frontiers in …, 2020 - frontiersin.org
Background and Objective Atrial fibrillation (AF), the most common cardiac arrhythmia,
typically increases with age. Oral anticoagulants (OACs) are the cornerstone of treatment to …