Pyroptosis is a form of programmed necrosis, and is morphologically and mechanistically
unique form of programmed cell death compared to others, such as apoptosis and …

There has been increasing interest in pyroptosis as a novel form of pro-inflammatory
programmed cell death. The mechanism of pyroptosis is significantly different from other …

Background. Extensive evidence has demonstrated that oxidative stress, pyroptosis, and
proinflammatory programmed cell death are related to renal ischemia/reperfusion (I/R) …

Background Immunotherapy has emerged as a significant strategy to treat numerous tumors.
The positive response to immunotherapy depends on the dynamic interaction between …

Reperfusion of the ischemic intestine often leads to drive distant organ injury, especially
injuries associated with hepatocellular dysfunction. The precise molecular mechanisms and …

Pyroptosis is a pattern of programmed cell death that significantly differs from apoptosis and
autophagy in terms of cell morphology and function. The process of pyroptosis is …

Background Lung ischemia–reperfusion injury (LIRI) is a complex pathophysiological
process that can lead to poor patient outcomes. Inflammasome-dependent macrophage …

Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is
exceptional from other types of cell death programs. Particularly, pyroptosis is characterized …

Ischemia/reperfusion (IR) injury contributes to disability and mortality worldwide. Due to the
complicated mechanisms and lack of proper therapeutic targets, few interventions are …

Background Pyroptosis, gasdermin-mediated programmed cell death, is readily induced in
macrophages by activation of the canonical inflammasome (caspase-1) or by intracellular …