A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics

J Anjum, S Mitra, R Das, R Alam, A Mojumder… - Pharmacological …, 2022 - Elsevier
Abnormalities in the mitogen-activated protein kinase (MAPK) signaling pathway are a key
contributor to the carcinogenesis process and have therefore been implicated in several …

Antioxidant and anti‐inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental …

H Parhiz, A Roohbakhsh, F Soltani… - Phytotherapy …, 2015 - Wiley Online Library
Inflammation and oxidative stress are two major causes of various life‐threatening diseases.
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species …

Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements

V Aggarwal, HS Tuli, F Thakral… - Experimental …, 2020 - journals.sagepub.com
Hesperidin belongs to flavanones class of flavonoids and is known to possess broad-
spectrum applicability to prevent dreadful diseases such as cardiovascular disease …

Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases

A Roohbakhsh, H Parhiz, F Soltani, R Rezaee… - Life sciences, 2015 - Elsevier
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species
that have various biological properties, particularly those for the prevention of cancer and …

Health-promoting effects of the citrus flavanone hesperidin

C Li, H Schluesener - Critical reviews in food science and nutrition, 2017 - Taylor & Francis
Hesperidin, a member of the flavanone group of flavonoids, can be isolated in large
amounts from the rinds of some citrus species. Considering the wide range of …

Phytochemistry and bioactivity of Citrus flavonoids: a focus on antioxidant, anti-inflammatory, anticancer and cardiovascular protection activities

L Yi, S Ma, D Ren - Phytochemistry Reviews, 2017 - Springer
Epidemiological studies have suggested an inverse relationship between increased
consumption of fruits and reduced risk of chronic diseases, such as cardiovascular diseases …

Mechanisms of cisplatin resistance and targeting of cancer stem cells: adding glycosylation to the equation

JA Ferreira, A Peixoto, M Neves, C Gaiteiro… - Drug Resistance …, 2016 - Elsevier
Cisplatin-based chemotherapeutic regimens are the most frequently used (neo) adjuvant
treatments for the majority of solid tumors. While platinum-based chemotherapeutic …

A comprehensive and current review on the role of flavonoids in lung cancer–Experimental and theoretical approaches

Ş Berk, S Kaya, EK Akkol, H Bardakçı - Phytomedicine, 2022 - Elsevier
Background It is well-known that flavonoids, which can be easily obtained from many fruits
and vegetables are widely preferred in the treatment of some important diseases. Some …

Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation

ST Ahmad, W Arjumand, S Nafees, A Seth, N Ali… - Toxicology letters, 2012 - Elsevier
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, but at high dose it
leads to undesirable side effects, such as hepatotoxicity and nephrotoxicity. The present …

[HTML][HTML] Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases

J Zou, J Wang, W Ye, J Lu, C Li, D Zhang, W Ye… - Biomedicine & …, 2022 - Elsevier
Abstract Citri Reticulatae Pericarpium (CRP) has been utilized as a versatile medicinal herb
with wide cardiovascular benefits in Asian nations for centuries. Accumulating evidence …