Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Quinolinic acid (QUIN), an endogenous metabolite of the kynurenine pathway, is involved in
several neurological disorders, including Huntington's disease, Alzheimer's disease …

Neurodegerative diseases have been linked to oxidative stress arising from peroxidation of
membrane biomolecules and high levels of Fe have been reported to play an important role …

Increased oxidative stress and mitochondrial dysfunction have been identified as common
pathophysiological phenomena associated with neurodegenerative disorders such as …

Reactive oxygen species have been demonstrated to be associated with a variety of
diseases including neurodegenerative disorders. Flavonoid compounds have been …

Glial cell line-derived neurotrophic factor (GDNF) is widely recognized as a potent survival
factor for dopaminergic neurons of the nigrostriatal pathway that degenerate in Parkinson's …

There is considerable evidence that pharmacological doses of the pineal hormone,
melatonin, are neuroprotective in diverse models of neurodegeneration including …

В книге обобщается большой литературный материал и результаты 20-ти летнего
опыта научных исследований сотрудников кафедры фармакологии СтГМА …

Metabolic syndrome is a global health problem in adults and its prevalence among children
and adolescents is rising. It is strongly linked to a lifestyle with high-caloric food, which …

Immune dysregulation observed in schizophrenia alters tryptophan metabolism. Tryptophan
metabolism is triggered by indoleamine 2, 3-dioxygenase (IDO) and tryptophan 2, 3 …