(Single-stranded DNA) gaps in understanding BRCAness
A Schreuder, TJ Wendel, CGV Dorresteijn… - Trends in Genetics, 2024 - cell.com
The tumour-suppressive roles of BRCA1 and 2 have been attributed to three seemingly
distinct functions–homologous recombination, replication fork protection, and single …
distinct functions–homologous recombination, replication fork protection, and single …
[HTML][HTML] Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection
I Ceppi, MR Dello Stritto, M Mütze, S Braunshier… - Nature, 2024 - nature.com
DNA double-strand break (DSB) repair by homologous recombination is initiated by DNA
end resection, a process involving the controlled degradation of the 5′-terminated strands …
end resection, a process involving the controlled degradation of the 5′-terminated strands …
[HTML][HTML] Positioning Loss of PARP1 Activity as the Central Toxic Event in BRCA-Deficient Cancer
NJ MacGilvary, SB Cantor - DNA repair, 2024 - Elsevier
The mechanisms by which poly (ADP-ribose) polymerase 1 (PARP1) inhibitors (PARPi) s
inflict replication stress and/or DNA damage are potentially numerous. PARPi toxicity could …
inflict replication stress and/or DNA damage are potentially numerous. PARPi toxicity could …
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
D Salas-Lloret, N García-Rodríguez… - Nature …, 2024 - nature.com
Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast
and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair …
and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair …
PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
C Andronikou, K Burdova, D Dibitetto, C Lieftink… - The EMBO …, 2024 - embopress.org
Targeting poly (ADP-ribose) glycohydrolase (PARG) is currently explored as a therapeutic
approach to treat various cancer types, but we have a poor understanding of the specific …
approach to treat various cancer types, but we have a poor understanding of the specific …
EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells
N García-Rodríguez, I Domínguez-García… - Nucleic Acids …, 2024 - academic.oup.com
DNA replication faces challenges from DNA lesions originated from endogenous or
exogenous sources of stress, leading to the accumulation of single-stranded DNA (ssDNA) …
exogenous sources of stress, leading to the accumulation of single-stranded DNA (ssDNA) …
[HTML][HTML] Tolerating DNA damage by repriming: Gap filling in the spotlight
T Jahjah, JK Singh, V Gottifredi, A Quinet - DNA repair, 2024 - Elsevier
Timely and accurate DNA replication is critical for safeguarding genome integrity and
ensuring cell viability. Yet, this process is challenged by DNA damage blocking the …
ensuring cell viability. Yet, this process is challenged by DNA damage blocking the …
[HTML][HTML] Exo1 cooperates with Tel1/ATM in promoting recombination events at DNA replication forks
M Galli, C Frigerio, CV Colombo, E Casari… - Iscience, 2024 - cell.com
Tel1/ataxia telangiectasia mutated (ATM) kinase plays multiple functions in response to DNA
damage, promoting checkpoint-mediated cell-cycle arrest and repair of broken DNA. In …
damage, promoting checkpoint-mediated cell-cycle arrest and repair of broken DNA. In …
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
A Schreuder, K de Lint, MM Gois, RA Kampen… - bioRxiv, 2024 - biorxiv.org
With the recent rise in CRISPR/Cas9-mediated genome-wide synthetic lethality screens,
many new synthetic lethal targets have been identified for diseases with underlying genetic …
many new synthetic lethal targets have been identified for diseases with underlying genetic …
Cell cycle regulation of polymerase theta mediated end-joining underlies its sensitivity to loss of BLM-DNA2
CP McBrine, RB Jensen, MC King - bioRxiv, 2024 - biorxiv.org
DNA double-strand breaks (DSBs) are predominantly resolved by the error-prone non-
homologous end-joining (NHEJ) or high-fidelity homologous recombination (HR) DNA …
homologous end-joining (NHEJ) or high-fidelity homologous recombination (HR) DNA …