Ca2+ channels and praziquantel: a view from the free world
JD Chan, M Zarowiecki, JS Marchant - Parasitology international, 2013 - Elsevier
Targeting the cellular Ca 2+ channels and pumps that underpin parasite Ca 2+ homeostasis
may realize novel antihelmintic agents. Indeed, the antischistosomal drug praziquantel …
may realize novel antihelmintic agents. Indeed, the antischistosomal drug praziquantel …
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels
Ion channels underlie a wide variety of physiological processes that involve rapid changes
in cell dynamics, such as cardiac and vascular smooth muscle contraction. Overexpression …
in cell dynamics, such as cardiac and vascular smooth muscle contraction. Overexpression …
In vivo neuromodulation of animal behavior with organic semiconducting oligomers
Modulating neural activity with electrical or chemical stimulus can be used for fundamental
and applied research. Typically, neuronal stimulation is performed with intracellular and …
and applied research. Typically, neuronal stimulation is performed with intracellular and …
Binding mechanism investigations guiding the synthesis of novel condensed 1, 4-dihydropyridine derivatives with L-/T-type calcium channel blocking activity
Nifedipine and isradipine are prominent examples of calcium channel blockers with a 1, 4-
dihydropyridine (DHP) scaffold. Although successfully used in clinics since decades for the …
dihydropyridine (DHP) scaffold. Although successfully used in clinics since decades for the …
[HTML][HTML] Control of low-threshold exocytosis by T-type calcium channels
N Weiss, GW Zamponi - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
Low-voltage-activated (LVA) T-type Ca2+ channels differ from their high-voltage-activated
(HVA) homologues by unique biophysical properties. Hence, whereas HVA channels …
(HVA) homologues by unique biophysical properties. Hence, whereas HVA channels …
Molecular nature of voltage‐gated calcium channels: structure and species comparison
The progression from one to three to 10, and in some instances more, voltage‐gated
calcium channels within living organisms during the course of evolution has paralleled the …
calcium channels within living organisms during the course of evolution has paralleled the …
[HTML][HTML] Divergent Ca2+/calmodulin feedback regulation of CaV1 and CaV2 voltage-gated calcium channels evolved in the common ancestor of Placozoa and …
Ca V 1 and Ca V 2 voltage-gated calcium channels evolved from an ancestral Ca V 1/2
channel via gene duplication somewhere near the stem animal lineage. The divergence of …
channel via gene duplication somewhere near the stem animal lineage. The divergence of …
[HTML][HTML] NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels
A Senatore, A Monteil, J van Minnen, AB Smit… - PLoS …, 2013 - journals.plos.org
NALCN is a member of the family of ion channels with four homologous, repeat domains that
include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene …
include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene …
[HTML][HTML] The calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1. 2 and Cav1. 3 channels
V Taiakina, AN Boone, J Fux, A Senatore… - PloS one, 2013 - journals.plos.org
NSCaTE is a short linear motif of (x W xxx (I or L) xxxx), composed of residues with a high
helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type …
helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type …
Evolution of excitation-contraction coupling
JJ Mackrill, HA Shiels - Calcium Signaling, 2020 - Springer
In mammalian cardiomyocytes, Ca 2+ influx through L-type voltage-gated Ca 2+ channels
(VGCCs) is amplified by release of Ca 2+ via type 2 ryanodine receptors (RyR2) in the …
(VGCCs) is amplified by release of Ca 2+ via type 2 ryanodine receptors (RyR2) in the …