Abstract Purpose of Review Cryopreservation and its associated freezing and thawing
procedures–short “freeze-thawing”–are among the final steps in economically viable …

The central goal of regenerative medicine is to replace damaged or diseased tissue with
cells that integrate and function optimally. The capacity of pluripotent stem cells to produce …

Immune cell–based therapies are promising strategies to facilitate immunosuppression
withdrawal after organ transplantation. Regulatory dendritic cells (DCreg) are innate …

Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing
autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population …

Regulatory T (Treg) cells are a heterogenous population of immunosuppressive T cells
whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is …

Tregs expressing chimeric antigen receptors (CAR-Tregs) are a promising tool to promote
transplant tolerance. The relationship between CAR structure and Treg function was studied …

Regulatory T (Treg) cells that express the transcription factor forkhead box protein P3
(FOXP3) are naturally present in the immune system and have roles in the maintenance of …

Organ transplants have been a life-saving form of treatment for many patients who are facing
end stage organ failure due to conditions such as diabetes, hypertension, various congenital …

Introduction Cell therapy with regulatory T cells (Tregs) in solid organ transplantation is a
promising approach for the prevention of graft rejection and induction of immunologic …

Advanced Therapy Medicinal Products (ATMPs) comprising cell, gene, and tissue-
engineered therapies have demonstrated enormous therapeutic benefits. However, their …