The science and medicine of human immunology
B Pulendran, MM Davis - Science, 2020 - science.org
BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …
detection and neutralization of pathogens. History is replete with the devastating effects of …
TSLP: from allergy to cancer
J Corren, SF Ziegler - Nature immunology, 2019 - nature.com
The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis
and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 …
and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 …
Dream: powerful differential expression analysis for repeated measures designs
GE Hoffman, P Roussos - Bioinformatics, 2021 - academic.oup.com
Large-scale transcriptome studies with multiple samples per individual are widely used to
study disease biology. Yet, current methods for differential expression are inadequate for …
study disease biology. Yet, current methods for differential expression are inadequate for …
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children
Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation
and pathology of multiple organs in individuals under 21 years of age in the weeks following …
and pathology of multiple organs in individuals under 21 years of age in the weeks following …
Food allergy and the microbiome: Current understandings and future directions
S Bunyavanich, MC Berin - Journal of Allergy and Clinical Immunology, 2019 - Elsevier
Growing evidence points to an important role for the commensal microbiota in susceptibility
to food allergy. Epidemiologic studies demonstrate associations between exposures known …
to food allergy. Epidemiologic studies demonstrate associations between exposures known …
Omics technologies in allergy and asthma research: An EAACI position paper
U Radzikowska, K Baerenfaller, JA Cornejo‐Garcia… - Allergy, 2022 - Wiley Online Library
Allergic diseases and asthma are heterogenous chronic inflammatory conditions with
several distinct complex endotypes. Both environmental and genetic factors can influence …
several distinct complex endotypes. Both environmental and genetic factors can influence …
The gut microbiome in food allergy
W Zhao, H Ho, S Bunyavanich - Annals of Allergy, Asthma & Immunology, 2019 - Elsevier
Objective To review observational human, murine, and interventional trial studies that have
examined the gut microbiome in food allergy, and to provide perspective on future …
examined the gut microbiome in food allergy, and to provide perspective on future …
Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
BM Al-Barghouthi, LD Mesner, GM Calabrese… - Nature …, 2021 - nature.com
Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000
associations; however, their impact has been limited by the difficulties of causal gene …
associations; however, their impact has been limited by the difficulties of causal gene …
Integrated study of systemic and local airway transcriptomes in asthma reveals causal mediation of systemic effects by airway key drivers
Background Systemic and local profiles have each been associated with asthma, but
parsing causal relationships between system-wide and airway-specific processes can be …
parsing causal relationships between system-wide and airway-specific processes can be …
Role of the microbiome in food allergy
H Ho, S Bunyavanich - Current Allergy and Asthma Reports, 2018 - Springer
Abstract Purpose of Review Resident microbial communities likely modify risk for allergic
disorders, including food allergy. We review epidemiologic studies linking microbial …
disorders, including food allergy. We review epidemiologic studies linking microbial …