BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …

The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis
and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 …

Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation
and pathology of multiple organs in individuals under 21 years of age in the weeks following …

Large-scale transcriptome studies with multiple samples per individual are widely used to
study disease biology. Yet, current methods for differential expression are inadequate for …

Growing evidence points to an important role for the commensal microbiota in susceptibility
to food allergy. Epidemiologic studies demonstrate associations between exposures known …

Objective To review observational human, murine, and interventional trial studies that have
examined the gut microbiome in food allergy, and to provide perspective on future …

Allergic diseases and asthma are heterogenous chronic inflammatory conditions with
several distinct complex endotypes. Both environmental and genetic factors can influence …

Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000
associations; however, their impact has been limited by the difficulties of causal gene …

Abstract Purpose of Review Resident microbial communities likely modify risk for allergic
disorders, including food allergy. We review epidemiologic studies linking microbial …

Background Unexpected allergic reactions to peanut are the most common cause of fatal
food-related anaphylaxis. Mechanisms underlying the variable severity of peanut-allergic …