MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …

Soon after the discovery of the Myc gene (c-Myc), it became clear that Myc expression levels
tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …

Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was
identified. Since that time, MYC research has been intense and the advances impressive …

For more than a decade, numerous studies have suggested that the c-Myc oncogenic
protein is likely to broadly influence the composition of the transcriptome. However, the …

The c-Myc oncogenic transcription factor (Myc) is pathologically activated in many human
malignancies. Myc is known to directly upregulate a pro-tumorigenic group of microRNAs …

The role of the myc gene family in the biology of normal and cancer cells has been
intensively studied since the early 1980s. myc genes, responding to diverse external and …

Much attention has focused on a small set of transcription factors that maintain human or
mouse embryonic stem (ES) cells in a pluripotent state. To gain a more complete …

Myc genes are key regulators of cell proliferation, and their deregulation contributes to the
genesis of most human tumours. Recently, a wealth of data has shed new light on the …