One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

The most frequent DNA lesion resulting from an oxidative stress is 7, 8-dihydro-8-
oxoguanine (8-oxoG). 8-oxoG is a premutagenic base modification due to its capacity to pair …

To perform their functions, transcription factors and DNA-repair/modifying enzymes
randomly search DNA in order to locate their specific targets on DNA. Discrete-state …

Protein-DNA interactions are critical for the successful functioning of all natural systems. The
key role in these interactions is played by processes of protein search for specific sites on …

What are the physical laws of the diffusive search of proteins for their specific binding sites
on DNA in the presence of the macromolecular crowding in cells? We performed extensive …

We adopt two-dimensional Langevin dynamics simulations to study the effective interactions
between two passive colloids in a bath crowded with active particles. We mainly pay …

Strong positional correlations between particles render the diffusion of a tracer particle in a
single file anomalous and non-Markovian. While ensemble average observables of tracer …

Using extensive computer simulations, we analyzed the role of physical properties of
molecular crowding agents such as size, shape and mobility in the target search dynamics …

Response time and transcription level are vital parameters of gene regulation. They depend
on how fast transcription factors (TFs) find and how efficient they occupy their specific target …

The key feature explaining the rapid recognition of a DNA target site by its protein lies in the
combination of one-and three-dimensional (1D and 3D) diffusion, which allows efficient …