Argonaute proteins (Agos) use small 15–30 nucleotide-long guides to bind and/or cleave
complementary target nucleic acids. Eukaryotic Agos mediate RNA-guided RNA silencing …

Our understanding of the evolution of DNA restriction and modification systems, the control
of the expression of the structural genes for the enzymes, and the importance of DNA …

This article continues the series of Surveys and Summaries on restriction endonucleases
(REases) begun this year in Nucleic Acids Research. Here we discuss 'Type II'REases, the …

Naturally occurring modification of the canonical A, G, C, and T bases can be found in the
DNA of cellular organisms and viruses from all domains of life. Bacterial viruses …

The halophile Halomonas TD01 and its derivatives have been successfully developed as a
low-cost platform for the unsterile and continuous production of chemicals. Therefore, to …

The construction of a variety of strains deficient in the methylation of adenine and cytosine
residues in DNA by the methyltransferases (MTases) Dam and Dcm has allowed the study of …

The 1952 observation of host-induced non-hereditary variation in bacteriophages by
Salvador Luria and Mary Human led to the discovery in the 1960s of modifying enzymes that …

A list of currently identified gene products of Escherichia coli is given, together with a
bibliography that provides pointers to the literature on each gene product. A scheme to …

Holliday junction resolvases (HJRs) are key enzymes of DNA recombination. A detailed
computer analysis of the structural and evolutionary relationships of HJRs and related …

McrBC-mediated restriction of modified DNA has been studied extensively by genetic
methods, but little is known of its molecular action. We have used overproducing plasmid …