Current clinical guidelines recommend mutation analysis for select codons in KRAS and
NRAS exons 2, 3, and 4 and BRAF V600E to guide therapy selection and prognostic …

Colorectal liver metastases (CRLMs) are clinically heterogeneous lesions with poor
prognosis. Genetic alterations play a crucial role in their progression. The traditional Fong …

Simple Summary There is a need to demonstrate additional clinical value/utility for PET/MRI
in oncology which moves beyond simple diagnosis. We believe that our currently submitted …

RAS oncogene family members are molecular switches of signaling pathways that control
cell growth, proliferation, differentiation, and survival. In colorectal cancer, Kirsten-RAS …

The molecular heterogeneity of KRAS is well established, with a pool of variants
comprising> 75% of all known mutations; this pool includes mutations in classic codons 12 …

In colorectal cancer (CRC), clinically relevant biomarkers are known for genome-guided
therapy that can be detected by both first and next generation methods. The aim of our work …

BRAF V600E-mutated colorectal cancer (CRC) is very aggressive and responds poorly to
standard treatment. In this study, BRAFV600E-mutant mice with CRC were treated with …

正电子发射断层成像术(positron emission tomography, PET)/计算机断层扫描(computed
tomography, CT) 显像可用于结肠癌的诊断, 监测疗效和预后评估. 18 F 标记葡萄糖(2-fluorine …

Colon and gastric cancers are the third and fifth cancer types with the poorest survival.
Surgery is considered the primary treatment option, which can be curative. However the …

Onkogen RAS memiliki peran dalam pertumbuhan dan regulasi sel. Protein ini
mempengaruhi banyak fungsi seluler termasuk proliferasi sel, diferensiasi, dan apoptosis …