Hypoxia-inducible factors and the regulation of lipid metabolism

I Mylonis, G Simos, E Paraskeva - Cells, 2019 - mdpi.com
Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions
and elicits a number of adaptive changes that are mainly mediated at the transcriptional …

Lipid metabolism in cancer

CR Santos, A Schulze - The FEBS journal, 2012 - Wiley Online Library
Lipids form a diverse group of water‐insoluble molecules that include triacylglycerides,
phosphoglycerides, sterols and sphingolipids. They play several important roles at cellular …

Pyroptosis: a pro-inflammatory type of cell death in cardiovascular disease

Q Wang, J Wu, Y Zeng, K Chen, C Wang, S Yang… - Clinica chimica acta, 2020 - Elsevier
Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by
gasdermin D (GSDMD)-mediated membrane pore formation, cell swelling and rapid lysis …

Hypoxia-inducible factors and the response to hypoxic stress

AJ Majmundar, WJ Wong, MC Simon - Molecular cell, 2010 - cell.com
Oxygen (O 2) is an essential nutrient that serves as a key substrate in cellular metabolism
and bioenergetics. In a variety of physiological and pathological states, organisms …

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

J Daniel, H Maamar, C Deb, TD Sirakova… - PLoS …, 2011 - journals.plos.org
Two billion people are latently infected with Mycobacterium tuberculosis (Mtb). Mtb-infected
macrophages are likely to be sequestered inside the hypoxic environments of the …

Characterization of a novel chicken muscle disorder through differential gene expression and pathway analysis using RNA-sequencing

MF Mutryn, EM Brannick, W Fu, WR Lee, B Abasht - BMC genomics, 2015 - Springer
Background Improvements in poultry production within the past 50 years have led to
increased muscle yield and growth rate, which may be contributing to an increased rate and …

PET imaging of inflammation in atherosclerosis

JM Tarkin, FR Joshi, JHF Rudd - Nature Reviews Cardiology, 2014 - nature.com
PET imaging of atherosclerosis can quantify several in vivo pathological processes
occurring within the arterial system. 18F-fluorodeoxyglucose (FDG) is the most-commonly …

Monocyte and macrophage immunometabolism in atherosclerosis

L Groh, ST Keating, LAB Joosten, MG Netea… - Seminars in …, 2018 - Springer
Atherosclerosis is characterized by chronic low grade inflammation of arteries that results in
the development of lipid dense plaques. Chronic inflammation induced by Western-type diet …

HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

JD Gordan, CB Thompson, MC Simon - Cancer cell, 2007 - cell.com
O 2 deprivation (hypoxia) and cellular proliferation engage opposite cellular pathways, yet
often coexist during tumor growth. The ability of cells to grow during hypoxia results in part …

Novel insights into the molecular mechanisms of atherosclerosis

A Wojtasińska, W Frąk, W Lisińska, N Sapeda… - International journal of …, 2023 - mdpi.com
Atherosclerosis is one of the most fatal diseases in the world. The associated thickening of
the arterial wall and its background and consequences make it a very composite disease …