Preclinical and clinical advances in transposon-based gene therapy
Transposons derived from Sleeping Beauty (SB), piggyBac (PB), or Tol2 typically require
cotransfection of transposon DNA with a transposase either as an expression plasmid or …
cotransfection of transposon DNA with a transposase either as an expression plasmid or …
[HTML][HTML] Transposons: moving forward from preclinical studies to clinical trials
K ChuahMarinee - Human gene therapy, 2017 - liebertpub.com
Transposons have emerged as promising vectors for gene therapy that can potentially
overcome some of the limitations of commonly used viral vectors. Transposons stably …
overcome some of the limitations of commonly used viral vectors. Transposons stably …
PiggyBac transposon-mediated gene transfer in human cells
Transposons are mobile genetic elements that can be used to integrate transgenes into host
cell genomes. The piggyBac transposon system has been used for transgenesis of insects …
cell genomes. The piggyBac transposon system has been used for transgenesis of insects …
Gene transfer into genomes of human cells by the sleeping beauty transposon system
Abstract The Sleeping Beauty (SB) transposon system, derived from teleost fish sequences,
is extremely effective at delivering DNA to vertebrate genomes, including those of humans …
is extremely effective at delivering DNA to vertebrate genomes, including those of humans …
Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors
Transposable elements can be considered as natural, non-viral gene delivery vehicles
capable of efficient genomic insertion. The plasmid-based transposon system of Sleeping …
capable of efficient genomic insertion. The plasmid-based transposon system of Sleeping …
Sleeping Beauty transposon‐mediated gene therapy for prolonged expression
Abstract The Sleeping Beauty (SB) transposon system represents a new vector for non‐viral
gene transfer that melds advantages of viruses and other forms of naked DNA transfer. The …
gene transfer that melds advantages of viruses and other forms of naked DNA transfer. The …
Transposons for gene therapy!
Gene therapy is a promising strategy for the treatment of several inherited and acquired
human diseases. Several vector platforms exist for the delivery of therapeutic nucleic acids …
human diseases. Several vector platforms exist for the delivery of therapeutic nucleic acids …
Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system
Gene transfer to the lung could provide important new treatments for chronic and acquired
lung diseases such as cystic fibrosis, α1-antitrypsin deficiency, emphysema, and cancer …
lung diseases such as cystic fibrosis, α1-antitrypsin deficiency, emphysema, and cancer …
Assembly of the Tc1 and mariner transposition initiation complexes depends on the origins of their transposase DNA binding domains
B Benjamin, B Yves, AG Corinne - Genetica, 2007 - Springer
In this review, we focus on the assembly of DNA/protein complexes that trigger transposition
in eukaryotic members of the IS630–Tc1–mariner (ITm) super-family, the Tc1-and mariner …
in eukaryotic members of the IS630–Tc1–mariner (ITm) super-family, the Tc1-and mariner …
Transposon vectors for gene‐trap insertional mutagenesis in vertebrates
The function of most vertebrate genes remains unknown or uncertain. Insertional
mutagenesis offers one approach to identify and understand the function of these genes …
mutagenesis offers one approach to identify and understand the function of these genes …