Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma

JA Vranka, MJ Kelley, TS Acott, KE Keller - Experimental eye research, 2015 - Elsevier
The trabecular meshwork (TM) is located in the anterior segment of the eye and is
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …

Exfoliation syndrome

R Ritch, U Schlötzer-Schrehardt - Survey of ophthalmology, 2001 - Elsevier
Exfoliation syndrome (XFS) is an age-related disease in which abnormal fibrillar
extracellular material is produced and accumulates in many ocular tissues. Its ocular …

Aqueous humor in glaucomatous eyes contains an increased level of TGF-β2

RC Tripathi, J Li, WFA Chan, BJ Tripathi - Experimental eye research, 1994 - Elsevier
By using the highly sensitive and specific technique of enzyme-linked immunosorbent
assay, we investigated the presence and amount of transforming growth factor-β2 (TGF-β2) …

Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork‐A review

KE Keller, DM Peters - Clinical & experimental ophthalmology, 2022 - Wiley Online Library
The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …

Open-angle glaucoma

HA Quigley - New England Journal of Medicine, 1993 - Mass Medical Soc
Our understanding of glaucoma has undergone dramatic changes in the past decade. The
ferment has derived from new epidemiologic information, improved diagnostic methods, and …

Extracellular matrix in the trabecular meshwork

TS Acott, MJ Kelley - Experimental eye research, 2008 - Elsevier
The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in
regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is …

The role of TGF-β in the pathogenesis of primary open-angle glaucoma

R Fuchshofer, ER Tamm - Cell and tissue research, 2012 - Springer
Transforming growth factor-β2 (TGF-β2) is found in increasing amounts in aqueous humor
and reactive optic nerve astrocytes of patients with primary open-angle glaucoma (POAG), a …

Changes in aqueous humor dynamics with age and glaucoma

PL Kaufman - Progress in retinal and eye research, 2005 - Elsevier
Changes in aqueous humor dynamics with age and in glaucoma have been studied for
several decades. More recently, techniques have been developed which confirm earlier …

[HTML][HTML] Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract

Y Takai, M Tanito, A Ohira - Investigative ophthalmology & …, 2012 - tvst.arvojournals.org
Purpose.: To measure levels of various inflammatory cytokines in the aqueous humor of
patients with primary open-angle glaucoma (POAG), exfoliation glaucoma (EXG), and senile …

Current concepts in the pathophysiology of glaucoma

R Agarwal, SK Gupta, P Agarwal… - Indian journal of …, 2009 - journals.lww.com
Glaucoma, the second leading cause of blindness, is characterized by changes in the optic
disc and visual field defects. The elevated intraocular pressure was considered the prime …