Beyond schistosomiasis: unraveling co-infections and altered immunity
DJ Perera, C Koger-Pease, K Paulini… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Schistosomiasis is a neglected tropical disease caused by the helminth Schistosoma spp.
and has the second highest global impact of all parasites. Schistosoma are transmitted …
and has the second highest global impact of all parasites. Schistosoma are transmitted …
Schistosomiasis mansoni-recruited eosinophils: An overview in the granuloma context
KK Malta, C Palazzi, VH Neves, Y Aguiar, TP Silva… - Microorganisms, 2022 - mdpi.com
Eosinophils are remarkably recruited during schistosomiasis mansoni, one of the most
common parasitic diseases worldwide. These cells actively migrate and accumulate at sites …
common parasitic diseases worldwide. These cells actively migrate and accumulate at sites …
Schistosoma mansoni co-infection modulates Chagas disease development but does not impair the effect of benznidazole-based chemotherapy
KJG Lozano, EG Santos, DFV Boas… - International …, 2024 - Elsevier
The adequate management of parasite co-infections represents a challenge that has not yet
been overcome, especially considering that the pathological outcomes and responses to …
been overcome, especially considering that the pathological outcomes and responses to …
Knocking Down Gm16685 Decreases Liver Granuloma in Murine Schistosomiasis Japonica
R Zhao, X Tang, H Lin, C Xing, N Xu, B Dai, P Wang… - Microorganisms, 2023 - mdpi.com
Long noncoding RNAs (lncRNAs) can regulate key genes and pathways in liver disease
development. Moreover, macrophages are speculated to play an important role in regulating …
development. Moreover, macrophages are speculated to play an important role in regulating …
Effects of Schistosoma haematobium infection and treatment on the systemic and mucosal immune phenotype, gene expression and microbiome: A systematic review
AM Mertelsmann, SF Bowers, D Wright… - PLOS Neglected …, 2024 - journals.plos.org
Background Urogenital schistosomiasis caused by Schistosoma haematobium affects
approximately 110 million people globally, with the majority of cases in low-and middle …
approximately 110 million people globally, with the majority of cases in low-and middle …
Macrophage MST1 protects against schistosomiasis-induced liver fibrosis by promoting the PPARγ-CD36 pathway and suppressing NF-κB signaling
J Li, X Cai, Y Yang, Y Mao, L Ding, Q Xue, X Hu… - PLoS …, 2024 - journals.plos.org
Schistosomiasis is characterized by egg-induced hepatic granulomas and subsequent
fibrosis. Monocyte-derived macrophages play critical and plastic roles in the progression …
fibrosis. Monocyte-derived macrophages play critical and plastic roles in the progression …
Schistosoma japonicum infection-mediated downregulation of lncRNA Malat1 contributes to schistosomiasis hepatic fibrosis by the Malat1/miR-96/Smad7 pathway
P Jiang, S Ye, X Fan, Y Tian, D Zhang, W Pan - Parasites & Vectors, 2024 - Springer
Background Schistosoma japonicum infection causes hepatic fibrosis, a primary cause of
morbidity and mortality associated with the disease, and effective treatments are still lacking …
morbidity and mortality associated with the disease, and effective treatments are still lacking …
Differential murine responses to Schistosoma mansoni eggs in the liver and small intestine lead to downmodulation of hepatic but not intestinal periovular …
A Montasser, AE Dakrory, MIM Ibrahim… - Infection and …, 2024 - journals.asm.org
To control schistosomiasis mansoni, it is important to attempt preventing the worms' egg-
induced pathology in the liver and limiting pathogen transmission following egg exit from the …
induced pathology in the liver and limiting pathogen transmission following egg exit from the …
Schistosome Infection Impacts Hematopoiesis
T Wijshake, J Rose III, J Wang, J Zielke… - The Journal of …, 2024 - journals.aai.org
Helminth infections are common in animals. However, the impact of a helminth infection on
the function of hematopoietic stem cells (HSCs) and other hematopoietic cells has not been …
the function of hematopoietic stem cells (HSCs) and other hematopoietic cells has not been …
Type I/II Immune Balance Contributes to the Protective Effect of AIF-1 on Hepatic Immunopathology Induced by Schistosoma japonicum in a Transgenic Mouse Model
J Lei, Y Feng, W Zheng, M Khamis, J Zhang, X Hou… - Inflammation, 2024 - Springer
Schistosomiasis is the second most debilitating neglected tropical disease in the world. Liver
egg granuloma and fibrosis are the main damage of schistosomiasis. In this study, the role of …
egg granuloma and fibrosis are the main damage of schistosomiasis. In this study, the role of …