During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal
uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is …

Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives
rise to cells with multipotent potential. EndMT is essential for the formation of the …

The placenta is crucial for a successful pregnancy and the health of both the fetus and the
pregnant woman. However, how the human trophoblast lineage is regulated, including the …

Abnormal placentation has been noticed in a variety of pregnancy complications such as
miscarriage, early-onset preeclampsia, and fetal growth restriction. Defects in the …

Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors,
which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell …

ABSTRACT A successful pregnancy depends on the intricate and timely interactions of
maternal and fetal cells. Placental extravillous cytotrophoblast invasion involves a cellular …

Implantation involves an extensive cross talk between the trophoblast cells and the receptive
endometrium through embryonic as well as endometrial‐derived factors that regulate the …

Following embryo implantation, extravillous trophoblasts (EVTs) invade the maternal
decidua to a certain extent during early pregnancy, which is critical for normal placentation …

Angiogenesis is a hallmark of cancer. However, most malignant solid tumors exhibit robust
resistance to current anti-angiogenic therapies that primarily target VEGF pathways. Here …

Therapeutic resistance remains a persistent challenge for patients with malignant tumors.
Here, we reveal that endothelial cells (ECs) acquire transformation into mesenchymal stem …