The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that
comprise the cellular microenvironment in tissues. Its alterations are fundamental to …

The extracellular milieu of tumors is generally assumed to be immunosuppressive due in
part to metabolic factors. Here, we review methods for probing the tumor metabolic …

The balance of programmed death-1 (PD-1)-expressing CD8+ T cells and regulatory T
(Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 …

Obesity is a major cancer risk factor, but how differences in systemic metabolism change the
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …

Brain metastases are refractory to therapies that control systemic disease in patients with
human epidermal growth factor receptor 2-positive breast cancer and the brain …

Rapidly proliferating tumor and immune cells need metabolic programs that support energy
and biomass production. The amino acid glutamine is consumed by effector T cells and …

Cancer cell metabolism is heavily influenced by microenvironmental factors, including
nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential …

How tumor-infiltrating T lymphocytes (TILs) adapt to the metabolic constrains within the
tumor microenvironment (TME) and to what degree this affects their ability to combat tumor …

Only a small percentage of patients afflicted with gastric cancer (GC) respond to immune
checkpoint blockade (ICB). To study the mechanisms underlying this resistance, we …

CD8+ T cell activation leads to the rapid proliferation and differentiation of effector T cells
(Teffs), which mediate antitumor immunity. Although aerobic glycolysis is preferentially …