Recent advances in research of natural and synthetic bioactive quinolines

PY Chung, ZX Bian, HY Pun, D Chan… - Future medicinal …, 2015 - Taylor & Francis
Many natural products that consist of quinoline core are found to be bioactive and the
versatility of quinoline and its derivatives have attracted great attention in the field of drug …

Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer

H Zhang, X Zhang, X Li, WB Meng… - Journal of cellular …, 2019 - Wiley Online Library
Pancreatic cancer (PC) is a serious malignancy with high mortality and poor prognosis due
to nonspecific incipient symptoms and early metastasis. Also, increasing evidence indicates …

Connexin's connection in breast cancer growth and progression

D Banerjee - International journal of cell biology, 2016 - Wiley Online Library
Gap junctions are cell‐to‐cell junctions that are located in the basolateral surface of two
adjoining cells. A gap junction channel is composed of a family of proteins called connexins …

Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome …

SY Li, R Sun, HX Wang, S Shen, Y Liu, XJ Du… - Journal of controlled …, 2015 - Elsevier
Aberrant DNA hypermethylation is critical in the regulation of renewal and maintenance of
cancer stem cells (CSCs), which represent targets for carcinogenic initiation by chemical …

The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU …

ZL Li, J Mi, L Lu, Q Luo, X Liu, YM Yan, B Jin… - Food & Function, 2021 - pubs.rsc.org
Anthocyanins have been reported to have effective chemopreventive activity. Lycium
ruthenicum Murray is rich in anthocyanins and exhibits many biological activities. The …

Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition

MS Nafie, SM Kishk, S Mahgoub… - Chemical Biology & …, 2022 - Wiley Online Library
Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …

One-step catalytic synthesis of alkyl-substituted quinolines

CE Meyet, CH Larsen - The Journal of Organic Chemistry, 2014 - ACS Publications
Difficult-to-access alkyl-substituted quinolines are formed directly from commercially
available anilines, aldehydes, and alkynes bearing a variety of substituents. Copper (II) …

Targeting connexin 43 with α–connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer …

CL Grek, JM Rhett, JS Bruce, MA Abt, GS Ghatnekar… - BMC cancer, 2015 - Springer
Background Treatment failure is a critical issue in breast cancer and identifying useful
interventions that optimize current cancer therapies remains a critical unmet need …

Synthesis of novel pyrimido[4,5‐b]quinolines as potential anticancer agents and HER2 inhibitors

NSM Ibrahim, HH Kadry, AF Zaher… - Chemical Biology & …, 2023 - Wiley Online Library
A series of N‐arylpyrimido [4, 5‐b] quinolines 3a–e and 2‐aryl‐2, 3‐dihydropyrimido [4, 5‐b]
quinoline‐4 (1 H)‐ones 5a–e was designed and synthesized as potential anticancer agents …

Connexin 43, breast cancer tumor suppressor: Missed connections?

CL Grek, JM Rhett, JS Bruce, GS Ghatnekar, ES Yeh - Cancer letters, 2016 - Elsevier
Connexins are a family of transmembrane proteins that are characterized by their capacity to
form intercellular channels called gap junctions that directly link the cytoplasm of adjacent …