Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

The i-motif represents a paradigmatic example of the wide structural versatility of nucleic
acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held …

Summary This integrated, multiplatform PanCancer Atlas study co-mapped and identified
distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites …

Radiation is a significant treatment for patients with head and neck cancer. Despite
advances to improve treatment, many tumors acquire radiation resistance resulting in poor …

Cancer therapy has advanced from tradition chemotherapy methods to targeted therapy,
novel drug delivery mechanisms, combination therapies etc. Although several novel …

The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle
assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family …

Controlled assembly and disassembly of multi-protein complexes is central to cellular
signaling. Proteins of the widespread and functionally diverse HORMA family nucleate …

Head and neck cancer is a highly genetic and metabolic heterogeneous collection of
malignancies of the lip, oral cavity, salivary glands, pharynx, esophagus, paranasal sinuses …

Background Thyroid hormone receptor interactor 13 (TRIP13) is an AAA+ ATPase that plays
an important role in the mitotic checkpoint. TRIP13 is highly expressed in various human …

Aberrant energy metabolism and cell cycle regulation both critically contribute to malignant
cell growth and both processes represent targets for anticancer therapy. It is shown here that …