Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …

The oral mucosal barrier is constantly exposed to a plethora of triggers requiring immune
control, including a diverse commensal microbiome, ongoing damage from mastication, and …

In their classic 1976 paper, Page & Schroeder described the histopathologic events and the
types of myeloid cells and lymphocytes involved in the initiation and progression of …

Periodontitis involves the loss of connective tissue attachment and alveolar bone. Single cell
RNA-seq experiments have provided new insight into how resident cells and infiltrating …

Resolution of inflammation is essential for tissue homeostasis and represents a promising
approach to inflammatory disorders. Here we found that developmental endothelial locus-1 …

Alveolar bone is a unique osseous tissue due to the proximity of dental plaque biofilms.
Periodontal health and homeostasis are mediated by a balanced host immune response to …

Periodontitis is an inflammatory disease characterized by the destruction of the
periodontium. In the last decade, a new murine model of periodontitis has been widely used …

Neutrophils have been historically associated with antimicrobial functions in acute infections
but are now appreciated as functionally versatile cells with critical roles in chronic …

Aim Osteoimmunology covers the cellular and molecular mechanisms responsible for
inflammatory osteolysis that culminates in the degradation of alveolar bone …

Periodontal disease is characterised by a dense inflammatory infiltrate in the connective
tissue. When the resolution is not achieved, the activation of T and B cells is crucial in …