Histological analysis of donor pancreases coupled with measurement of serum C-peptide in
clinical cohorts has challenged the idea that all beta cells are eventually destroyed in type 1 …

Endocrine homeostasis and metabolic diseases have been the subject of extensive
research in recent years. The development of new techniques and insights has led to a …

Pancreatic islets are richly vascularized, and islet blood vessels are uniquely adapted to
maintain and support the internal milieu of the islets favoring normal endocrine function. Islet …

Identification of cell-surface markers specific to human pancreatic β cells would allow in vivo
analysis and imaging. Here we introduce a biomarker, ectonucleoside triphosphate …

Functional nanomaterials have been widely used in biomedical fields due to their good
biocompatibility, excellent physicochemical properties, easy surface modification, and easy …

The prevalence of diabetes mellitus, which currently affects 387 million people worldwide, is
permanently rising in both adults and adolescents. Despite numerous treatment options …

Since diabetes is becoming a global epidemic, there is a great need to develop early β-cell
specific diagnostic techniques for this disorder. There are two types of diabetes (ie, type 1 …

Numerous studies have sought to decipher the genetic and other mechanisms contributing
to β-cell loss and dysfunction in diabetes mellitus. However, we have yet to fully understand …

The Innovative Medicines Initiative (IMI) is a public-private partnership between the
European Union and the European pharmaceutical industry. Born of the necessity to foster …

Although convincing in genetic models, the relevance of β-cell insulin resistance in diet-
induced type 2 diabetes (T2DM) remains unclear. Exemplified by diabetes-prone, male …