Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

Maintenance of skeletal muscle mass is regulated by the balance between anabolic and
catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved …

Skeletal muscle fibers are classified into fiber types, in particular, slow twitch versus fast
twitch. Muscle fiber types are generally defined by the particular myosin heavy chain …

Aging is characterized by the development of metabolic dysfunction and frailty. Recent
studies show that a reduction in nicotinamide adenine dinucleotide (NAD+) is a key factor for …

Skeletal muscle mass increases during postnatal development through a process of
hypertrophy, ie enlargement of individual muscle fibers, and a similar process may be …

During the past decade, skeletal muscle has been identified as a secretory organ.
Accordingly, we have suggested that cytokines and other peptides that are produced …

Skeletal muscle is a plastic organ that is maintained by multiple pathways regulating cell
and protein turnover. During muscle atrophy, proteolytic systems are activated, and …

Cancer cachexia is characterized by a significant reduction in body weight resulting
predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced …

The molecular mechanisms underlying skeletal muscle maintenance involve interplay
between multiple signaling pathways. Under normal physiological conditions, a network of …