Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …

RNA-based therapy is a promising and potential strategy for disease treatment by
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …

With the integration of nanotechnology into the medical field at large, great strides have
been made in the development of nanomedicines for tackling different diseases, including …

Oligonucleotides (ONs) comprise a rapidly growing class of therapeutics. In recent years, the
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …

Therapeutic RNA molecules possess high potential for treating medical conditions if they
can successfully reach the target cell upon administration. However, unmodified RNA …

Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of
people around the globe and are a major public health burden. Most contemporary …

Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream
with Janus kinases (JAK) family protein and capable of integrating inputs from different …

Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Therapeutic alteration of gene expression in vivo can be achieved by delivering nucleic
acids (eg, mRNA, siRNA) using nanoparticles. Recent progress in modified messenger RNA …