Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory
failure due to acute respiratory distress syndrome (ARDS). Paradoxically, mechanical …

Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer
(PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic …

Obligate protozoan parasites of the kinetoplastids and apicomplexa infect human cells to
complete their life cycles. Some of the members of these groups of parasites develop in at …

HSP90 is a molecular chaperone required for stabilization and activation of hundreds of
client proteins, including many known oncoproteins. AUY922 (luminespib), a new …

Nuclear receptors are transcription factors that play critical roles in development,
homeostasis and metabolism in all multicellular organisms. An important family of nuclear …

Simple Summary There is a widespread push toward more biologically relevant pre-clinical
models of prostate cancer that can improve the discovery and translation of new drugs and …

Precision medicine has emerged as an important paradigm in oncology, driven by the
significant heterogeneity of individual patients' tumour. A key prerequisite for effective …

Abstract Background Inhibition of Hsp90 is desirable due to potential downregulation of
oncogenic clients. Early generation inhibitors bind to the N-terminal domain (NTD) but C …

In the context of our SAR study concerning 6BrCaQ analogues as C-terminal Hsp90
inhibitors, we designed and synthesized a novel series of 3-(heteroaryl) quinolin-2 (1 H), of …

Inhibition of the heat shock protein 90 (Hsp90) chaperone is a promising therapeutic
strategy to target expression of the androgen receptor (AR) and other oncogenic drivers in …