Immunoglobulin gene sequence as an inherited and acquired risk factor for chronic lymphocytic leukemia

M Datta, H Jumaa - Cancers, 2022 - mdpi.com
Simple Summary Chronic lymphocytic leukemia (CLL) is the most prevalent among adult
leukemias. Over the years, several research efforts discovered a lot of intricate details about …

Diagnosis and Molecular Pathology of Lymphoblastic Leukemias and Lymphomas in the Era of Genomics and Precision Medicine: Historical Evolution and Current …

R Kansal - Lymphatics, 2023 - mdpi.com
The diagnosis and treatment of lymphoid neoplasms have undergone a continuously
progressive positive change in the last three decades, with accelerated progress in the …

Clinicobiological characteristics and treatment efficacy of novel agents in chronic lymphocytic leukemia with IGLV3-21R110

PJ Hengeveld, YE Ertem, JMN Dubois, CHM Mellink… - Leukemia, 2022 - nature.com
The molecular composition of the leukemia-specific B cell receptor (BCR) is of key
importance in chronic lymphocytic leukemia (CLL)[1]. Firstly, using the burden of somatic …

Prevalence of IGLV3-21R110 among familial CLL: a retrospective study of 45 cases

M Armand, P Verrier, F Theves, C Bravetti… - Blood …, 2022 - ashpublications.org
Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia in adults in
western countries. Family studies demonstrated that first-degree relatives of patients with …

The determinants of B cell receptor signaling as prototype molecular biomarkers of leukemia

A Nicolò, AT Linder, H Jumaa, PC Maity - Frontiers in Oncology, 2021 - frontiersin.org
Advanced genome-wide association studies (GWAS) identified several transforming
mutations in susceptible loci which are recognized as valuable prognostic markers in …

[PDF][PDF] MOLECULAR ANALYSIS OF IMMUNOGLOBULIN GENE REARRANGEMENTS AND THEIR SIGNIFICANCE IN B-CELL LYMPHOPROLIFERATIONS

MK Stránská - is.muni.cz
In up to 25% of chronic lymphocytic leukemia (CLL) patients, multiple clonal productive
immunoglobulin heavy chain gene rearrangements (MP-IGHs) can be detected, suggesting …

[PDF][PDF] MOLECULAR ANALYSIS OF IMMUNOGLOBULIN GENE REARRANGEMENTS AND THEIR SIGNIFICANCE IN B-CELL LYMPHOPROLIFERATIONS

MK Plevová, MK Stránská - is.muni.cz
In up to 25% of chronic lymphocytic leukemia (CLL) patients, multiple clonal productive
immunoglobulin heavy chain gene rearrangements (MP-IGHs) can be detected, suggesting …