Telomeres and telomere length: a general overview

N Srinivas, S Rachakonda, R Kumar - Cancers, 2020 - mdpi.com
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Recent advances in arsenic research: significance of differential susceptibility and sustainable strategies for mitigation

T Sanyal, P Bhattacharjee, S Paul… - Frontiers in public …, 2020 - frontiersin.org
Arsenic contamination in drinking water and associated adverse outcomes are one of the
major health issues in more than 50 countries worldwide. The scenario is getting even more …

Associations between prenatal multiple plasma metal exposure and newborn telomere length: Effect modification by maternal age and infant sex

P Tang, W He, Y Shao, B Liu, H Huang, J Liang… - Environmental …, 2022 - Elsevier
Exposure to metals during pregnancy may affect maternal and infant health. However,
studies on the combined effects of metals on the telomere length (TL) of newborns are …

Impact of prenatal heavy metal exposure on newborn leucocyte telomere length: A birth-cohort study

KM Wai, M Umezaki, S Kosaka, O Mar… - Environmental …, 2018 - Elsevier
Arsenic, cadmium and lead are toxic environmental contaminants. They were shown to be
associated with telomere length (TL) in adults. Although they can cross the placental barrier …

Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?

KM Wai, T Swe, MT Myar, CR Aisyah… - Frontiers in Public …, 2023 - frontiersin.org
Maintaining telomere length plays a crucial role in regulating cellular life span. Telomere
lengthening or shortening is one of the important biomarkers which could predict the …

Protective role of selenium in the shortening of telomere length in newborns induced by in utero heavy metal exposure

KM Wai, M Umezaki, M Umemura, O Mar… - Environmental …, 2020 - Elsevier
The effects of toxic heavy metals, such as arsenic (As), cadmium (Cd), and lead (Pb), on
telomere length (TL) have been reported previously. Although selenium (Se) is considered …

Telomere length, arsenic exposure and risk of basal cell carcinoma of skin

N Srinivas, S Rachakonda, T Hielscher… - …, 2019 - academic.oup.com
Telomere length per se a heritable trait has been reported to be associated with different
diseases including cancers. In this study, based on arsenic-exposed 528 cases with basal …

Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology

P Møller, RS Wils, DM Jensen… - Critical Reviews in …, 2018 - Taylor & Francis
There has been a steady output of epidemiological studies linking environmental and
occupational exposures to altered telomere length, showing mainly positive associations …

Epigenetic regulations in alternative telomere lengthening: understanding the mechanistic insight in arsenic-induced skin cancer patients

P Bhattacharjee, A Das, AK Giri - Science of the total environment, 2020 - Elsevier
Telomere integrity is considered to be one of the primary mechanisms during malignant
transformation. Arsenic, a group 1 carcinogenic metalloid, has been reported to cause …

[HTML][HTML] Co-exposure to multiple metals, TERT-CLPTM1L variants, and their joint influence on leukocyte telomere length

Y Bai, W Fu, X Guan, X Wu, G Li, W Wei, Y Feng… - Environment …, 2020 - Elsevier
Objective Telomere is required for maintaining chromosome stability and genome integrity,
while telomere length is sensitive to environmental stressors. We aimed to identify the effects …