• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Heart failure (HF) is a heterogeneous clinical syndrome marked by substantial morbidity and
mortality. The natural history of HF is well established; however, epidemiological data are …

Background One of the major determinants of exercise intolerance and limiting symptoms
among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated …

Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease characterized by
prominent “non-ischemic” myocardial scarring predisposing to ventricular electrical …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure and cardiac
transplantation. We report a genome-wide association study and multi-trait analysis of DCM …

Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is not a dichotomous
disease trait. Technological innovations enable long-term rhythm monitoring in many …

Youth and adult participation in sports continues to increase, and athletes may be
diagnosed with potentially arrhythmogenic cardiac conditions. This international …

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy
worldwide, affecting approximately 1 in 500 individuals. Current therapeutic interventions …

Abstract Background and Aims Pathogenic desmoplakin (DSP) gene variants are
associated with the development of a distinct form of arrhythmogenic cardiomyopathy known …

Background Obstructive hypertrophic cardiomyopathy (oHCM) is characterized by left
ventricular (LV) hypertrophy, LV outflow tract obstruction, and left atrial dilation, which can be …