The state of complement in COVID-19

B Afzali, M Noris, BN Lambrecht… - Nature Reviews …, 2022 - nature.com
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

[HTML][HTML] Effects of COVID-19 on the nervous system

C Iadecola, J Anrather, H Kamel - Cell, 2020 - cell.com
Neurological complications have emerged as a significant cause of morbidity and mortality
in the ongoing COVID-19 pandemic. Beside respiratory insufficiency, many hospitalized …

Lifting the mask on neurological manifestations of COVID-19

A Pezzini, A Padovani - Nature Reviews Neurology, 2020 - nature.com
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic spreads, it
is becoming increasingly evident that coronavirus disease 2019 (COVID-19) is not limited to …

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …

Anticoagulation, bleeding, mortality, and pathology in hospitalized patients with COVID-19

GN Nadkarni, A Lala, E Bagiella, HL Chang… - Journal of the American …, 2020 - jacc.org
Background Thromboembolic disease is common in coronavirus disease-2019 (COVID-19).
There is limited evidence on the association of in-hospital anticoagulation (AC) with …

COVID‐19: a global threat to the nervous system

IJ Koralnik, KL Tyler - Annals of neurology, 2020 - Wiley Online Library
In less than 6 months, the severe acute respiratory syndrome‐coronavirus type 2 (SARS‐
CoV‐2) has spread worldwide infecting nearly 6 million people and killing over 350,000 …

Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position paper

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
Cytokine storm is an acute hyperinflammatory response that may be responsible for critical
illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure …

[HTML][HTML] The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

TP Buzhdygan, BJ DeOre, A Baldwin-Leclair… - Neurobiology of …, 2020 - Elsevier
As researchers across the globe have focused their attention on understanding SARS-CoV-
2, the picture that is emerging is that of a virus that has serious effects on the vasculature in …

Microthrombi as a major cause of cardiac injury in COVID-19: a pathologic study

D Pellegrini, R Kawakami, G Guagliumi, A Sakamoto… - Circulation, 2021 - Am Heart Assoc
Background: Cardiac injury is common in patients who are hospitalized with coronavirus
disease 2019 (COVID-19) and portends poorer prognosis. However, the mechanism and the …

Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Week

R Kawakami, A Sakamoto, K Kawai, A Gianatti… - Journal of the American …, 2021 - jacc.org
To investigate whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)–
induced myocarditis constitutes an important mechanism of cardiac injury, a review was …