Highlights•Discovery of pharmaceutical cocrystals has evolved from serendipity to
design.•Contains an overview of all commercially available pharmaceutical …

The incidence of preterm birth is increasing, leading to a growing population with potential
long-term pulmonary complications. Apnoea of prematurity (AOP) is one of the major …

The objective of lung development is to generate an organ of gas exchange that provides
both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly …

Neonatal hypoxic-ischemic encephalopathy (HIE) is a condition that results in brain damage
in newborns due to insufficient blood and oxygen supply during or after birth. HIE is a major …

Background Methylxanthine, including caffeine citrate and aminophylline, is the most
common pharmacologic treatment for apnea of prematurity. However, due to the lack of high …

METHODS: Thirteen academic hospitals in Canada, Australia, Great Britain, and Sweden
participated in this part of the 11-year follow-up of the double-blind, randomized, placebo …

Recently, pharmaceutical cocrystals have gained immense interest because of their
potential to tune mechanical, pharmacokinetic, and physicochemical properties of active …

BACKGROUND: Although caffeine use for apnea of prematurity is well studied, the long-
term safety and benefit of routine early caffeine administration has not been explored. Our …

Background Intestinal microenvironmental perturbations may increase food allergy risk. We
hypothesize that children with clinical food allergy, those with food sensitization, and healthy …

Background. Caffeine is widely used for the treatment of neonatal apnea, but there is no
agreement on the optimum maintenance dose for preterm infants. Objective. The aims of this …