Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

S Gnat, D Łagowski… - Journal of applied …, 2020 - academic.oup.com
Dermatophytes are the aetiological factors of a majority of superficial fungal infections. What
distinguishes them from other pathogenic filamentous fungi is their unique ability to degrade …

[HTML][HTML] Dermatophyte resistance to antifungal drugs: mechanisms and prospectus

NM Martinez-Rossi, TA Bitencourt, NTA Peres… - Frontiers in …, 2018 - frontiersin.org
Dermatophytes comprise pathogenic fungi that have a high affinity for the keratinized
structures present in nails, skin, and hair, causing superficial infections known as …

Antifungal resistance mechanisms in dermatophytes

NM Martinez-Rossi, NTA Peres, A Rossi - Mycopathologia, 2008 - Springer
Although fungi do not cause outbreaks or pandemics, the incidence of severe systemic
fungal infections has increased significantly, mainly because of the explosive growth in the …

Pathogenesis of dermatophytosis

S Vermout, J Tabart, A Baldo, A Mathy, B Losson… - Mycopathologia, 2008 - Springer
Despite the superficial localization of most dermatophytosis, host-fungus relationship in
these infections is complex and still poorly elucidated. Though many efforts have been …

Dermatophyte virulence factors: identifying and analyzing genes that may contribute to chronic or acute skin infections

RR Achterman, TC White - International journal of microbiology, 2012 - Wiley Online Library
Dermatophytes are prevalent causes of cutaneous mycoses and, unlike many other fungal
pathogens, are able to cause disease in immunocompetent individuals. They infect …

Generating and testing molecular hypotheses in the dermatophytes

TC White, BG Oliver, Y Gräser, MR Henn - Eukaryotic cell, 2008 - Am Soc Microbiol
Dermatophytes are the most common cause of fungal infections worldwide, impacting
millions of individuals annually. In the United States alone, this translates into an economic …

[HTML][HTML] Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte …

TA Bitencourt, TT Komoto, BG Massaroto… - … and alternative medicine, 2013 - Springer
Background Fatty acid synthase (FAS) is a promising antifungal target due to its marked
structural differences between fungal and mammalian cells. The aim of this study was to …

Differential gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus during infection

P Staib, C Zaugg, B Mignon, J Weber… - …, 2010 - microbiologyresearch.org
Although dermatophytes are the most common agents of superficial mycoses in humans and
animals, the molecular basis of the pathogenicity of these fungi is largely unknown. In vitro …

rpb2 is a reliable reference gene for quantitative gene expression analysis in the dermatophyte Trichophyton rubrum

TR Jacob, NTA Peres, GF Persinoti, LG Silva… - Medical …, 2012 - academic.oup.com
The selection of reference genes used for data normalization to quantify gene expression by
real-time PCR amplifications (qRT-PCR) is crucial for the accuracy of this technique. In spite …

[HTML][HTML] Transcriptional profiling reveals the expression of novel genes in response to various stimuli in the human dermatophyte Trichophyton rubrum

NTA Peres, PR Sanches, JP Falcão, HCS Silveira… - BMC microbiology, 2010 - Springer
Background Cutaneous mycoses are common human infections among healthy and
immunocompromised hosts, and the anthropophilic fungus Trichophyton rubrum is the most …