Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment
Abstract In 2010, the World Health Organization (WHO) established an indoor air quality
guideline for short-and long-term exposures to formaldehyde (FA) of 0.1 mg/m 3 (0.08 ppm) …
guideline for short-and long-term exposures to formaldehyde (FA) of 0.1 mg/m 3 (0.08 ppm) …
Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data
J Menz, ME Götz, U Gündel, R Gürtler, K Herrmann… - Archives of …, 2023 - Springer
Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a
binary classification of chemical entities. For more than a decade, there has been a …
binary classification of chemical entities. For more than a decade, there has been a …
Toxicity testing in the 21st century: a vision and a strategy
D Krewski, D Acosta Jr, M Andersen… - Journal of Toxicology …, 2010 - Taylor & Francis
With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a
Strategy, the US National Academy of Sciences, in 2007, precipitated a major change in the …
Strategy, the US National Academy of Sciences, in 2007, precipitated a major change in the …
Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment
An important goal in toxicology is the development of new ways to increase the speed,
accuracy, and applicability of chemical hazard and risk assessment approaches. A …
accuracy, and applicability of chemical hazard and risk assessment approaches. A …
The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium
JR Harkema, SA Carey, JG Wagner - Toxicologic pathology, 2006 - journals.sagepub.com
The nose is a very complex organ with multiple functions that include not only olfaction, but
also the conditioning (eg, humidifying, warming, and filtering) of inhaled air. The nose is also …
also the conditioning (eg, humidifying, warming, and filtering) of inhaled air. The nose is also …
Formaldehyde carcinogenicity research: 30 years and counting for mode of action, epidemiology, and cancer risk assessment
JA Swenberg, BC Moeller, K Lu… - Toxicologic …, 2013 - journals.sagepub.com
Formaldehyde is a widely used high production chemical that is also released as a
byproduct of combustion, off-gassing of various building products, and as a fixative for …
byproduct of combustion, off-gassing of various building products, and as a fixative for …
Cancer effects of formaldehyde: a proposal for an indoor air guideline value
GD Nielsen, P Wolkoff - Archives of toxicology, 2010 - Springer
Formaldehyde is a ubiquitous indoor air pollutant that is classified as “Carcinogenic to
humans (Group 1)”(IARC, Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropanol-2-ol …
humans (Group 1)”(IARC, Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropanol-2-ol …
A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure
RS Thomas, BC Allen, A Nong, L Yang… - Toxicological …, 2007 - academic.oup.com
The use of genomic technology for assessing health risks associated with chemical
exposure has significant potential, but its direct application has proven to be challenging for …
exposure has significant potential, but its direct application has proven to be challenging for …
Ranking cancer risks of organic hazardous air pollutants in the United States
Background In this study we compared cancer risks from organic hazardous air pollutants
(HAPs) based on total personal exposure summed across different microenvironments and …
(HAPs) based on total personal exposure summed across different microenvironments and …
Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia
K Lu, LB Collins, H Ru, E Bermudez… - Toxicological …, 2010 - academic.oup.com
Inhaled formaldehyde is classified as a known human and animal carcinogen, causing
nasopharyngeal cancer. Additionally, limited epidemiological evidence for leukemia in …
nasopharyngeal cancer. Additionally, limited epidemiological evidence for leukemia in …