Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment

GD Nielsen, ST Larsen, P Wolkoff - Archives of toxicology, 2017 - Springer
Abstract In 2010, the World Health Organization (WHO) established an indoor air quality
guideline for short-and long-term exposures to formaldehyde (FA) of 0.1 mg/m 3 (0.08 ppm) …

Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data

J Menz, ME Götz, U Gündel, R Gürtler, K Herrmann… - Archives of …, 2023 - Springer
Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a
binary classification of chemical entities. For more than a decade, there has been a …

Toxicity testing in the 21st century: a vision and a strategy

D Krewski, D Acosta Jr, M Andersen… - Journal of Toxicology …, 2010 - Taylor & Francis
With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a
Strategy, the US National Academy of Sciences, in 2007, precipitated a major change in the …

Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment

EJ Perkins, R Ashauer, L Burgoon… - Environmental …, 2019 - Wiley Online Library
An important goal in toxicology is the development of new ways to increase the speed,
accuracy, and applicability of chemical hazard and risk assessment approaches. A …

The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium

JR Harkema, SA Carey, JG Wagner - Toxicologic pathology, 2006 - journals.sagepub.com
The nose is a very complex organ with multiple functions that include not only olfaction, but
also the conditioning (eg, humidifying, warming, and filtering) of inhaled air. The nose is also …

Formaldehyde carcinogenicity research: 30 years and counting for mode of action, epidemiology, and cancer risk assessment

JA Swenberg, BC Moeller, K Lu… - Toxicologic …, 2013 - journals.sagepub.com
Formaldehyde is a widely used high production chemical that is also released as a
byproduct of combustion, off-gassing of various building products, and as a fixative for …

Cancer effects of formaldehyde: a proposal for an indoor air guideline value

GD Nielsen, P Wolkoff - Archives of toxicology, 2010 - Springer
Formaldehyde is a ubiquitous indoor air pollutant that is classified as “Carcinogenic to
humans (Group 1)”(IARC, Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropanol-2-ol …

A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure

RS Thomas, BC Allen, A Nong, L Yang… - Toxicological …, 2007 - academic.oup.com
The use of genomic technology for assessing health risks associated with chemical
exposure has significant potential, but its direct application has proven to be challenging for …

Ranking cancer risks of organic hazardous air pollutants in the United States

MM Loh, JI Levy, JD Spengler… - Environmental …, 2007 - ehp.niehs.nih.gov
Background In this study we compared cancer risks from organic hazardous air pollutants
(HAPs) based on total personal exposure summed across different microenvironments and …

Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia

K Lu, LB Collins, H Ru, E Bermudez… - Toxicological …, 2010 - academic.oup.com
Inhaled formaldehyde is classified as a known human and animal carcinogen, causing
nasopharyngeal cancer. Additionally, limited epidemiological evidence for leukemia in …