Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Many biological tissues, such as wood and bone, are fiber composites with a hierarchical
structure. Their exceptional mechanical properties are believed to be due to a functional …

The vast osteocytic network is believed to orchestrate bone metabolic activity in response to
mechanical stimuli through production of sclerostin, RANKL, and osteoprotegerin (OPG) …

Bone is able to react to changing mechanical demands by adapting its internal
microstructure through bone forming and resorbing cells. This process is called bone …

Osteocyte sclerostin is regulated by loading and disuse in mouse tibiae but is more closely
related to subsequent local osteogenesis than the peak strains engendered. Introduction …

There is a widely held view that the relationship between mechanical loading history and
adult bone mass/strength includes an adapted state or “lazy zone” where the bone …

Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

OBJECTIVE: Post-traumatic osteoarthritis (PTOA) is a common consequence of traumatic
joint injury, with 50% of anterior cruciate ligament (ACL) rupture patients developing PTOA …