Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a
major cause of incurable vision loss. Tremendous progress has been made over the last two …

There are two vascular networks in mammals that coordinately function as the main supply
and drainage systems of the body. The blood vasculature carries oxygen, nutrients …

INTRODUCTION Vision provides a critical survival advantage but requires a tight coupling
between neuronal energy demands and their vascular supply. The degeneration and …

Attenuating pathological angiogenesis in diseases characterized by neovascularization
such as diabetic retinopathy has transformed standards of care. Yet little is known about the …

Pathological angiogenesis in the eye is an important feature in the pathophysiology of many
vision-threatening diseases, including retinopathy of prematurity, diabetic retinopathy, and …

Heart is a complex assembly of many cell types constituting myocardium, endocardium and
epicardium that intensively communicate to each other in order to maintain the proper …

Functional interactions between neurons, vasculature, and glia within neurovascular units
are critical for maintenance of the retina and other CNS tissues. For example, the …

Abstract Aims Methylation of CpG island promoters is a prototypical epigenetic mechanism
to stably control gene expression. The aim of this study was to elucidate the contribution of …

Vascular mimicry is induced by a wide array of genes with functions related to cancer
stemness, hypoxia, angiogenesis and autophagy. Vascular mimicry competent (VM …

Age-related macular degeneration (AMD) is the primary cause of blindness in developed
countries, and is the third leading cause worldwide. Emerging evidence suggests that …