[HTML][HTML] Microsatellite markers: what they mean and why they are so useful

MLC Vieira, L Santini, AL Diniz… - Genetics and molecular …, 2016 - SciELO Brasil
Abstract Microsatellites or Single Sequence Repeats (SSRs) are extensively employed in
plant genetics studies, using both low and high throughput genotyping approaches …

Neurodegenerative diseases: implications of environmental and climatic influences on neurotransmitters and neuronal hormones activities

EA Ayeni, AM Aldossary, DA Ayejoto… - International Journal of …, 2022 - mdpi.com
Neurodegenerative and neuronal-related diseases are major public health concerns.
Human vulnerability to neurodegenerative diseases (NDDs) increases with age. Neuronal …

An RNA-targeting CRISPR–Cas13d system alleviates disease-related phenotypes in Huntington's disease models

KH Morelli, Q Wu, ML Gosztyla, H Liu, M Yao… - Nature …, 2023 - nature.com
Huntington's disease (HD) is a fatal, dominantly inherited neurodegenerative disorder
caused by CAG trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Since the …

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

AC Woerner, F Frottin, D Hornburg, LR Feng… - Science, 2016 - science.org
Amyloid-like protein aggregation is associated with neurodegeneration and other
pathologies. The nature of the toxic aggregate species and their mechanism of action …

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models

JA Bush, H Aikawa, R Fuerst, Y Li, A Ursu… - Science translational …, 2021 - science.org
The most common cause of amyotrophic lateral sclerosis and frontotemporal dementia
(c9ALS/FTD) is an expanded G4C2 RNA repeat [r (G4C2) exp] in chromosome 9 open …

Polyglutamine (PolyQ) Diseases: Navigating the Landscape of Neurodegeneration

R Tenchov, JM Sasso, QA Zhou - ACS Chemical Neuroscience, 2024 - ACS Publications
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders
caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with …

Fetal liver hematopoietic stem cell niches associate with portal vessels

JA Khan, A Mendelson, Y Kunisaki, A Birbrair, Y Kou… - Science, 2016 - science.org
Whereas the cellular basis of the hematopoietic stem cell (HSC) niche in the bone marrow
has been characterized, the nature of the fetal liver niche is not yet elucidated. We show that …

Machado–Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy

CA Matos, LP de Almeida… - Journal of …, 2019 - Wiley Online Library
Abstract Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3
(SCA 3), is an incurable disorder, widely regarded as the most common form of …

RNA-binding proteins in neurodegeneration: mechanisms in aggregate

EG Conlon, JL Manley - Genes & development, 2017 - genesdev.cshlp.org
Neurodegeneration is a leading cause of death in the developed world and a natural, albeit
unfortunate, consequence of longer-lived populations. Despite great demand for therapeutic …

Gene therapy for neurodegenerative diseases: slowing down the ticking clock

R Martier, P Konstantinova - Frontiers in Neuroscience, 2020 - frontiersin.org
Gene therapy is an emerging and powerful therapeutic tool to deliver functional genetic
material to cells in order to correct a defective gene. During the past decades, several …