PI3K inhibitors are finally coming of age
Abstract Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation
has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has …
has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has …
Kinase inhibitors: the road ahead
FM Ferguson, NS Gray - Nature reviews Drug discovery, 2018 - nature.com
Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …
Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment
Immune checkpoint inhibitors (ICIs) have revolutionized the clinical management of multiple
tumours. However, only a few patients respond to ICIs, which has generated considerable …
tumours. However, only a few patients respond to ICIs, which has generated considerable …
Signaling pathways in inflammation and anti-inflammatory therapies
YT Yeung, F Aziz, A Guerrero-Castilla… - Current …, 2018 - ingentaconnect.com
During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …
[HTML][HTML] PI3K signalling in inflammation
PT Hawkins, LR Stephens - … et Biophysica Acta (BBA)-Molecular and Cell …, 2015 - Elsevier
PI3Ks regulate several key events in the inflammatory response to damage and infection.
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …
Ten things you should know about protein kinases: IUPHAR R eview 14
D Fabbro, SW Cowan‐Jacob… - British journal of …, 2015 - Wiley Online Library
Many human malignancies are associated with aberrant regulation of protein or lipid
kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein …
kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials
C Fritsch, A Huang, C Chatenay-Rivauday… - Molecular cancer …, 2014 - AACR
Somatic PIK3CA mutations are frequently found in solid tumors, raising the hypothesis that
selective inhibition of PI3Kα may have robust efficacy in PIK3CA-mutant cancers while …
selective inhibition of PI3Kα may have robust efficacy in PIK3CA-mutant cancers while …
A review of the molecular aspects of melatonin's anti‐inflammatory actions: recent insights and new perspectives
Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …
by the pineal gland, but also by other nonendocrine organs, of most mammals including …
Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings
T Pap, A Korb-Pap - Nature Reviews Rheumatology, 2015 - nature.com
Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …