Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …

The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their
cellular responses by binding to and activating the different isoforms encoded by the four …

We analyzed the effects of an FGF‐23 injection in vivo. FGF‐23 caused a reduction in serum
1, 25‐dihydroxyvitamin D by altering the expressions of key enzymes for the vitamin D …

FGF23 is a unique member of the fibroblast growth factor (FGF) family because it acts as a
hormone that derives from bone and regulates kidney functions, whereas most other family …

The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-
deficient mice exhibit a variety of aging-like phenotypes, many of which are similar to those …

Phosphate homeostasis is maintained by a counterbalance between efflux from the kidney
and influx from intestine and bone. FGF23 is a bone-derived phosphaturic hormone that acts …

The regulation of the phosphaturic factor fibroblast growth factor 23 (FGF23) is not well
understood. It was found that administration of 1, 25-dihydroxyvitamin D 3 (1, 25 [OH] 2 D 3) …

FGF signaling plays a ubiquitous role in human biology as a regulator of embryonic
development, homeostasis and regenerative processes. In addition, aberrant FGF signaling …

Fibroblast growth factor-23 (FGF23) is a phosphaturic hormone that contributes to several
hypophosphatemic disorders by reducing the expression of the type II sodium-phosphate …

Fibroblast growth factors (FGFs) are key regulators of several developmental processes in
which cell fate and differentiation to various tissue lineages are determined. The importance …