There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Germline commitment following primordial germ cell (PGC) specification during early human
development establishes an epigenetic programme and competence for gametogenesis …

The evolution of embryo models | Nature Methods Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Abstract Development requires coordinated interactions between the epiblast, which
generates the embryo proper; the trophectoderm, which generates the placenta; and the …

Embryogenesis necessitates harmonious coordination between embryonic and
extraembryonic tissues. Although stem cells of both embryonic and extraembryonic origins …

Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts
termed blastoids upon switch to inductive medium. However, the underlying mechanisms …

Research focused on human reproductive biology has primarily relied upon clinical samples
affording mainly descriptive studies with limited implementation of functional or mechanistic …

Successful human pregnancy depends upon rapid establishment of three founder lineages:
the trophectoderm, epiblast and hypoblast, which together form the blastocyst. Each plays …