Monoligated palladium (0) species, L1Pd (0), have emerged as the most active catalytic
species in the cross-coupling cycle. Today, there are methods available to generate the …

A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …

Proteins are the most abundant biomolecules within a cell and are involved in all
biochemical cellular processes, fulfilling specific functions with unmatched precision. This …

Bioconjugation chemistry has been used to prepare modified biomolecules with functions
beyond what nature intended. Central to these techniques is the development of highly …

In the last decade, visible‐light photoredox catalysis has emerged as a powerful strategy to
enable novel transformations in organic synthesis. Owing to mild reaction conditions (ie …

An efficient method for chemoselective cysteine arylation of unprotected peptides and
proteins using Au (III) organometallic complexes is reported. The bioconjugation reactions …

Peptides hold great promise in proteomics, diagnostics and drug discovery. While natural
peptides continue to be of key importance, chemically modified unnatural peptides have …

Late-stage specific and selective diversifications of peptides and proteins performed at
target residues under ambient conditions are recognized to be the most facile route to …