Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations

LF Yang, M Ling, N Kacherovsky, SH Pun - Chemical Science, 2023 - pubs.rsc.org
Aptamers are single-stranded nucleic acids that bind and recognize targets much like
antibodies. Recently, aptamers have garnered increased interest due to their unique …

Reactor configuration, operations and structural catalyst design in process intensification of catalytic reactors: A review

GA Tafete, NG Habtu - Chemical Engineering and Processing-Process …, 2023 - Elsevier
Catalytic reactors are playing a vital role in many process industries especiallyby advancing
chemical transformations in a sustainable wayand at a reseonable cost. However, catalytic …

Affinity monolith chromatography: A review of general principles and recent developments

S Poddar, S Sharmeen, DS Hage - Electrophoresis, 2021 - Wiley Online Library
Affinity monolith chromatography (AMC) is a liquid chromatographic technique that utilizes a
monolithic support with a biological ligand or related binding agent to isolate, enrich, or …

Membrane chromatography and fractionation of proteins from whey—A review

A Nath, MM Zin, MA Molnár, S Bánvölgyi, I Gáspár… - Processes, 2022 - mdpi.com
Membrane chromatography (MC) is an emerging bioseparation technology combining the
principles of membrane filtration and chromatography. In this process, one type of molecule …

Comparative evaluation of commercial protein A membranes for the rapid purification of antibodies

J Osuofa, SM Husson - Membranes, 2023 - mdpi.com
Protein A chromatography is ubiquitous to antibody purification. The high specificity of
Protein A for binding the Fc-region of antibodies and related products enables unmatched …

Convection rather than diffusion for fast efficient mRNA vaccine purification

R Banik, TG Neuman, Z Hao, M Al Sharabati… - Separation and …, 2025 - Elsevier
In the rush to produce mRNA vaccines and ensure integrity and purity, capital-intensive
purification steps were used, typically involving slow diffusion-driven, inefficient, and costly …

Mechanistic modeling of empty‐full separation in recombinant adeno‐associated virus production using anion‐exchange membrane chromatography

J Gomis‐Fons, B Zee, D Hurwit, J Woo… - Biotechnology and …, 2024 - Wiley Online Library
Recombinant adeno‐associated viral vectors (rAAVs) have become an industry‐standard
technology in the field of gene therapy, but there are still challenges to be addressed in their …

[HTML][HTML] Recent advances in accelerating solid-phase extraction

J Zhou, Y Chang, H Tian, JH Qu, Q Wang… - Journal of …, 2024 - Elsevier
With the growing demand for rapid processing of laboratory samples, great efforts have
been dedicated to improving the speed and throughput of solid phase extraction (SPE), a …

Purification of monoclonal antibody using cation exchange z2 laterally-fed membrane chromatography–A potential alternative to protein A affinity chromatography

R Roshankhah, G Chen, Y Xu, N Butani… - Biochemical …, 2022 - Elsevier
Protein A affinity chromatography, which is the standard method for purifying monoclonal
antibodies (mAbs) is expensive and involves elution at acidic pH, which could degrade the …

Magnetic composite membrane roll column for rapid and high efficiency separation of antibodies

J Zhou, C Zuo, H Tian, W Wang, J Yang… - Separation and …, 2023 - Elsevier
The increase in upstream titers of monoclonal antibodies puts enormous pressure on
downstream processes, therefore new purification technology is desired. In this study …