Anticancer drugs are often nonselective antiproliferative agents (cytotoxins) that
preferentially kill dividing cells by attacking their DNA at some level. The lack of selectivity …

Gene therapy of cancer offers the possibility of a targeted treatment that destroys tumors and
metastases, but not normal tissues. In gene-directed enzyme prodrug therapy (GDEPT), or …

Gene delivery efficiency in clinical cancer gene therapy trials with recombinant
adenoviruses (Ads) based on serotype 5 (Ad5) has been limited partly because of variable …

Ovarian cancer is the most lethal gynecological malignancy in the developed world. In spite
of intensive research, the mortality has hardly decreased over the past twenty years. This …

Purpose To evaluate the feasibility and safety of adenovirus-mediated gene therapy as a
treatment for tumor seeds in the vitreous of children with retinoblastoma. Patients and …

Abstract Adenovirus serotype 5 (Ad5) displays unparalleled gene transfer efficacy to cells
with high coxsackie-adenovirus receptor (CAR) expression. Unfortunately, cells isolated …

Purpose: Delineation of the long-term follow-up data on a series of patients with malignant
mesothelioma, who received a single intrapleural dose of a nonreplicative adenoviral (Ad) …

Abstract Characterization of particulate impurities such as aggregates is necessary to
develop safe and efficacious adeno-associated virus (AAV) drug products. Although …

Gene therapy is an exciting novel approach for treating cancers resistant to currently
available modalities. Treatment approaches are based on taking advantage of molecular …

Gene therapy manipulates or modifies a gene that provides a new cellular function to treat or
correct a pathological condition, such as cancer. The approach of using gene manipulation …