The AlkB family of Fe (II)/α-ketoglutarate-dependent dioxygenases: repairing nucleic acid alkylation damage and beyond
The AlkB family of Fe (II)-and α-ketoglutarate-dependent dioxygenases is a class of
ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases …
ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases …
C H Bond Activation in Transition Metal Species from a Computational Perspective
Alkanes constitute the cheapest and most abundant feedstock for organic chemicals.
However, the redistribution of CsC and CsH bonds in hydrocarbons into more sophisticated …
However, the redistribution of CsC and CsH bonds in hydrocarbons into more sophisticated …
[HTML][HTML] Structural insight into substrate preference for TET-mediated oxidation
DNA methylation is an important epigenetic modification,,. Ten-eleven translocation (TET)
proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine …
proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine …
Quantum mechanics/molecular mechanics modeling of enzymatic processes: Caveats and breakthroughs
MG Quesne, T Borowski… - Chemistry–A European …, 2016 - Wiley Online Library
Nature has developed large groups of enzymatic catalysts with the aim to transfer substrates
into useful products, which enables biosystems to perform all their natural functions. As …
into useful products, which enables biosystems to perform all their natural functions. As …
TET family proteins: oxidation activity, interacting molecules, and functions in diseases
DNA modification is one of the most widely studied epigenetic modifications in high
eukaryotic systems. Modified DNA bases impact gene regulation beyond the primary DNA …
eukaryotic systems. Modified DNA bases impact gene regulation beyond the primary DNA …
Quantum mechanics/molecular mechanics study on the oxygen binding and substrate hydroxylation step in AlkB repair enzymes
AlkB repair enzymes are important nonheme iron enzymes that catalyse the demethylation
of alkylated DNA bases in humans, which is a vital reaction in the body that heals externally …
of alkylated DNA bases in humans, which is a vital reaction in the body that heals externally …
Ascorbic Acid Reprograms Epigenome and Epitranscriptome by Reducing Fe (III) in the Catalytic Cycle of Dioxygenases
W He, X Yin, C Xu, X Liu, Y Huang, C Yang… - ACS Chemical …, 2023 - ACS Publications
Ascorbic acid (ASC) has been reported to stimulate DNA iterative oxidase ten-eleven
translocation (TET) enzymes, Jumonji C-domain-containing histone demethylases, and …
translocation (TET) enzymes, Jumonji C-domain-containing histone demethylases, and …
Catalytic mechanism of human ten-eleven translocation-2 (tet2) enzyme: Effects of conformational changes, electric field, and mutations
SO Waheed, SS Chaturvedi… - ACS …, 2021 - ACS Publications
Ten-eleven translocation (TET) family of enzymes are non-heme Fe (II)-and 2-oxoglutarate
(2OG)-dependent oxygenases that perform oxidation of the methyl group of the 5 …
(2OG)-dependent oxygenases that perform oxidation of the methyl group of the 5 …
Role of structural dynamics in selectivity and mechanism of non-heme Fe (II) and 2-oxoglutarate-dependent oxygenases involved in DNA repair
AlkB and its human homologue AlkBH2 are Fe (II)-and 2-oxoglutarate (2OG)-dependent
oxygenases that repair alkylated DNA bases occurring as a consequence of reactions with …
oxygenases that repair alkylated DNA bases occurring as a consequence of reactions with …
Nucleic acid oxidation in DNA damage repair and epigenetics
Methylation is a widely occurring chemical modification in nucleic acids and proteins.
Methylating agents, either extracellular or intracellular, can attack vulnerable sites in DNA …
Methylating agents, either extracellular or intracellular, can attack vulnerable sites in DNA …