Yellow fever virus: knowledge gaps impeding the fight against an old foe
Yellow fever (YF) was one of the most dangerous infectious diseases of the 18th and 19th
centuries, resulting in mass casualties in Africa and the Americas. The etiologic agent is …
centuries, resulting in mass casualties in Africa and the Americas. The etiologic agent is …
Innovations, challenges, and minimal information for standardization of humanized mice
Mice xenotransplanted with human cells and/or expressing human gene products (also
known as “humanized mice”) recapitulate the human evolutionary specialization and …
known as “humanized mice”) recapitulate the human evolutionary specialization and …
[HTML][HTML] Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
A Segovia-Zafra, DE Di Zeo-Sánchez… - … Pharmaceutica Sinica B, 2021 - Elsevier
Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that
prescription and non-prescription drugs, herbal and dietary supplements can cause to the …
prescription and non-prescription drugs, herbal and dietary supplements can cause to the …
Experimental in vitro and in vivo models for the study of human hepatitis B virus infection
L Allweiss, M Dandri - Journal of hepatology, 2016 - Elsevier
Chronic infection with the hepatitis B virus (HBV) affects an estimate of 240 million people
worldwide despite the availability of a preventive vaccine. Medication to repress viral …
worldwide despite the availability of a preventive vaccine. Medication to repress viral …
[HTML][HTML] Extensive double humanization of both liver and hematopoiesis in FRGN mice
Preclinical research in animals often fails to adequately predict the outcomes observed in
human patients. Chimeric animals bearing individual human tissues have been developed …
human patients. Chimeric animals bearing individual human tissues have been developed …
Animal models of hepatitis B virus infection–success, challenges, and future directions
Chronic hepatitis B virus (HBV) infection affects more than 250 million people worldwide,
which greatly increases the risk for terminal liver diseases, such as liver cirrhosis and …
which greatly increases the risk for terminal liver diseases, such as liver cirrhosis and …
[HTML][HTML] Viral load affects the immune response to HBV in mice with humanized immune system and liver
M Dusséaux, G Masse-Ranson, S Darche, J Ahodantin… - Gastroenterology, 2017 - Elsevier
Background & Aims Hepatitis B virus (HBV) infects hepatocytes, but the mechanisms of the
immune response against the virus and how it affects disease progression are unclear …
immune response against the virus and how it affects disease progression are unclear …
Humanized mice efficiently engrafted with fetal hepatoblasts and syngeneic immune cells develop human monocytes and NK cells
Background & Aims Human liver chimeric mice are useful models of human hepatitis virus
infection, including hepatitis B and C virus infections. Independently, immunodeficient mice …
infection, including hepatitis B and C virus infections. Independently, immunodeficient mice …
Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein
Objective The recent availability of novel antiviral drugs has raised new hope for a more
effective treatment of hepatitis C virus (HCV) infection and its severe sequelae. However, in …
effective treatment of hepatitis C virus (HCV) infection and its severe sequelae. However, in …
Hepatitis delta virus: From biological and medical aspects to current and investigational therapeutic options
D Alfaiate, P Dény, D Durantel - Antiviral research, 2015 - Elsevier
An estimated 15–20 million individuals are co-infected by hepatitis B and hepatitis D virus
worldwide and are at high risk of developing end-stage liver disease, including …
worldwide and are at high risk of developing end-stage liver disease, including …