Cyclophosphamide (CP) is an important anticancer drug which belongs to the class of
alkylating agent. Cyclophosphamide is mostly used in bone marrow transplantation …

Spectral count, defined as the total number of spectra identified for a protein, has gained
acceptance as a practical, label-free, semiquantitative measure of protein abundance in …

Background: Non-invasive diagnostic strategies aimed at identifying biomarkers of cancer
are of great interest for early cancer detection. Urine is potentially a rich source of volatile …

Spectral counting has become a commonly used approach for measuring protein
abundance in label-free shotgun proteomics. At the same time, the development of data …

Mutations in the gene encoding the RNA-binding protein RBM20 have been implicated in
dilated cardiomyopathy (DCM), a major cause of chronic heart failure, presumably through …

Background—After myocardial ischemia, extracellular matrix (ECM) deposition occurs at the
site of the focal injury and at the border region. Methods and Results—We have applied a …

Placental abnormalities are associated with two of the most common and serious
complications of human pregnancy, maternal preeclampsia (PE) and fetal intrauterine …

Developments in subcellular fractionation strategies have provided the means to profile and
analyze the protein composition of organelles and cellular structures by proteomics. Here …

Delineating human cardiac pathologies and their basic molecular mechanisms relies on
research conducted in model organisms. Yet translating findings from preclinical models to …

Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …