Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure
to targeted anticancer agents. This process, termed lineage plasticity, is associated with …

Lung cancer is the leading cause of cancer-related deaths worldwide. With a focus on
histology, there are two major subtypes: Non-small cell lung cancer (NSCLC)(the more …

Over the past several years, we have witnessed a resurgence of interest in the biology and
therapeutic vulnerabilities of small-cell lung cancer (SCLC). This has been driven in part …

Small‑cell lung cancer (SCLC) is a type of lung cancer with early metastasis, and high
recurrence and mortality rates. The molecular mechanism is still unclear and further …

Background: Small Cell Lung Cancer (SCLC) is a highly aggressive malignancy. MYC
family oncogenes are amplified and overexpressed in 20% of SCLCs, showing that MYC …

Simple Summary Small cell lung cancer (SCLC) is a fatal malignant tumor with a poor
prognosis for patients who relapse after first-line treatment. There are few effective …

MYCN, a member of the MYC family, is correlated with tumorigenesis, metastasis and
therapy in many malignancies; however, its role in small-cell lung cancer (SCLC) remains …

Somatic alterations in tumors are a frequent occurrence. In small cell lung cancer (SCLC),
these include mutations in the tumor suppressors TP53 and retinoblastoma (RB1). We used …

Abstract The World Health Organization (WHO) has defined more than 130 distinct central
nervous system (CNS) tumor entities, of which glioblastoma is the most fatal primary brain …

Background Previous studies have demonstrated that prophylactic cranial irradiation (PCI)
could reduce the risk of brain metastases and prolong the overall survival (OS) of patients …